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The Procter Gamble Company

Dwight M Peterson

Rajan Keshav Panandiker

Christiaan A Thoen

Pierre M Lenoir

James E Thompson

The present invention relates to analogues of 2,7-diaminomitosene, a mitomycin C metabolite, useful as antitumor, antimicrobial and/or antiviral agents. These analogues involve functionalization of the N-2 nitrogen with organic groups.

2,7-diaminomitosene analogues

Included is a liquid detergent composition comprising detersive surfactant, proteolytic enzyme, a detergent-compatible second enzyme, and an aryl boronic acid of the structure: ##STR1## where X is selected from C.sub.1 -C.sub.6 alkyl, substituted C.sub.1 -C.sub.6 alkyl, aryl, substituted aryl, hydroxyl, hydroxyl derivative, amine, C.sub.1 -C.sub.6 alkylated amine, amine derivative, halogen, nitro, thiol, thiol derivative, aldehyde, acid, acid salt, ester, sulfonate or phosphonate; each Y is independently selected from hydrogen, C.sub.1 -C.sub.6 alkyl, substituted C.sub.1 -C.sub.6 alkyl, aryl, substituted aryl, hydroxyl, hydroxyl derivative, halogen, amine, alkylated amine, amine derivative, nitro, thiol, thiol derivative, aldehyde, acid, ester, sulfonate or phosphonate; and n is 0 to 4.

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Wyoming, OH, United States of America

Dwight M Peterson