Roche Molecular Systems, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Dwight Kuo

Ann Begovich

Xiaoju Max Ma

Ellen C Ordinario

Rajiv Dua

Chitra Manohar

Cindy Cheung

Grantland Hillman

Huan Truong

Javelin Chi

Michael Lee

Jaya Rajamani

Provided herein are methods and compositions for multiplex detection of a large number of actionable gene fusions with very high sensitivity and specificity. The present methods and compositions can detect ALK, RET, and ROS1 gene fusions, optionally in combination with other mutations and fusions.

Multiplex PCR detection of ALK, RET, and ROS fusions

Provided herein are methods and compositions for detecting gene fusions, e.g., relevant to cancer. The present methods and compositions can be used to detect gene fusions with very high sensitivity and specificity. The present methods and compositions can detect gene fusions, e.g., in free circulating tumor RNA from a plasma sample.

Multiplex PCR to detect gene fusions

Growing community of inventors

Castro Valley, CA, United States of America

Dwight Kuo