The University of Texas System

Illumina Corporation

Dwight Baker

James C Sacchettini

Chen Zhao

Kevin Eric Wu

Nian E Zhou

Deeann Wallis

Niam Zhou

Steven A Maxwell

Han-Yu Chuang

Alex So

Tatjana Singer

Jennifer Lococo

Steve Maxwell

The disclosed embodiments concern methods, systems and computer program products for determining sequences of interest using unique molecular indexes (UMIs) that are uniquely associable with individual polynucleotide fragments, including sequences with low allele frequencies or long sequence length. In some implementations, the UMIs include variable-length nonrandom UMIs (vNRUMIs). Methods and systems for making and using sequencing adapters comprising vNRUMIs are also provided.

Universal short adapters with variable length non-random unique molecular identifiers

The disclosure provides rifamycin and rifamycin derivative compositions, including rifabutin and rifabutin derivative compositions able to cause drug-sensitization in a cancer cell or inhibition of a cancer cell. The disclosure also provides methods of administering such compositions to cancer cells to sensitize them to drugs, such as chemotherapeutics, or directly inhibit them. The disclosure also provides methods of administering such compositions to increase reactive oxygen species (ROS), particularly superoxides, in cancer cells. The disclosure further provides methods of determining whether a cancer will respond to chemotherapeutics and whether to administer rifamycin or a rifamycin derivative based on ROS levels in cancer cells of a patient.

Compositions and methods for drug-sensitization or inhibition of a cancer cell

Growing community of inventors

College Station, TX, United States of America

Dwight Baker