Nanostring Technologies, Inc.

The University of Texas System

Bruker Spatial Biology, Inc.

Institute for Systems Biology

Dwayne L Dunaway

Joseph M Beechem

Rustem Khafizov

Sanghamithra Korukonda

Mark Gregory

Margaret Hoang

Dae Kim

Yi Deng

Elizabeth A Manrao

Jaemyeong Jung

Gordon B Mills

Charles Warren

Scott Crowder

Chris Merritt

Isaac Sprague

Qian Mei

Krassen M Dimitrov

Michael Krouse

Lucas M Dennis

Kristina Sorg

Gavin Meredith

Mark McElwain

Peter Skene

Cassandra Burke

Sean M Ferree

Lidan Wu

Matthew J Walsh

Grant Tremel

Peter E Schultz

Matthew Walsh

Evan Perillo

Krassen Dimitrov

Eliot Sosin

Lucas Dennis

Shanshan He

Tushar Rane

Jonathan Cheng

Isabel Lee

The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.

Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue

The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.

Chemical compositions and methods of using same

Embodiments of the present disclosure are directed to a compact, mobile, digital spatial profiling (DSP) system, and associated apparatuses, devices and methods, which are configured to image one or more regions-of-interest (ROIs), and then using UV light to cleave, for example, oligos off antibodies in one or more ROIs ('photocleaving'), and collect the photocleaved oligos for later hybridization and counting.

Methods, apparatuses, systems and devices for mobile digital spatial profiling of pathological specimens

The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.

Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue

The present disclosure is directed to systems, devices and methods for nucleic acid or protein purification and imaging. A system is provided including a cartridge comprising a sample input area configured to hold a sample, comprising a plurality of hybridized complexes comprising a plurality of target molecules each hybridized with probes and a plurality of non-hybridized probes. The cartridge may also include a first binding chamber configured with first magnetic beads to receive and bind the sample, a first elution channel configured to receive the first magnetic beads and elute the sample from the first magnetic beads, a second binding chamber configured with second magnetic beads to receive and bind the sample, a second elution channel configured to receive the second magnetic beads and elute the sample from the second magnetic beads, and a binding area configured to receive the eluted sample and hold molecules for imaging.

Methods and apparatuses for gene purification and imaging

The invention provides methods, compositions, kits and devices for the detection of proteins. In some embodiments, the invention allows for multiplexed protein detection.

Protein detection via nanoreporters

Growing community of inventors

Seattle, WA, United States of America

Dwayne L Dunaway