Scientific Generics Limited

Sensortec Limited

Duncan Ross Purvis

Andrew Nicholas Dames

Philip Nigel Bartlett

Colin D Ager

Olga Leonardova

Nicholas A Safford

Vladimir Rurikovich Tcherkassov

Dmitri Alexandrovich Farmakovski

The invention relates to methods of preparation of highly sensitive potentiometric sensors with an electroconductive polymer film as a sensing element.

Methods for producing highly sensitive potentiometric sensors

A method of electrochemical analysis using a sensor electrode specific for an analyte under test. The method comprises immersing the sensor electrode in a sample solution suspected of containing the analyte; forming an electrochemically active complex by exposure to solutions containing secondary receptors or competing molecules labelled with a charged or enzyme label; and subsequently exposing the sensor to an electrochemically active solution. The measurement step comprises driving the sensor electrode potential to a predetermined fixed potential by applying a current or activation waveform then monitoring the potential difference between the sensor electrode and a reference electrode following removal of the holding current. Current, rate and potential can all be measured and used to determine analyte concentration or sensor state.

Method of electrochemical analysis of an analyte

Particles are separated according to their dielectrophoretic characteristics and electrorotation characteristics by the use of a travelling wave separation in which they flow from a departure point at an inlet (,) towards at least two destinations at outlets (,) and are deflected toward one or other outlet according to their characteristics by a travelling wave field set up on an array of electrodes, each electrode running generally in the direction of flow.

Methods of analysis/separation

This invention provides methods for denaturing nucleic acids. The methods involve contacting a solution comprising double stranded nucleic acid with a surface having denaturation activity sufficient to produce denaturation within a period of not more than one hour.

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Royston, United Kingdom

Duncan Ross Purvis