Amgen Inc.

Duncan M Smith

Ning Xi

Michael G Kelly

Mark Henry Norman

Christopher Harold Fotsch

Shimin Xu

Nuria A Tamayo

Ning Chen

Qingyian Liu

Markian Myroslaw Stec

Nianhe Han

Elizabeth M Doherty

Michael D Croghan

Yunxin Y Bo

Premilla Arasasingham

Martin H Goldberg

Feng-Yin Hsieh

Selected substituted piperazine compounds of Formula Iare effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Substituted piperazinyl amides and methods of use

Selected substituted piperidine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Substituted piperidines and methods of use

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Thousand Oaks, CA, United States of America

Duncan M Smith