Medimmune Limited

Amgen Inc.

Duncan James Cochrane

Jamie Iain Campbell

David C Lowe

Simon Charles Cruwys

Maria Anastasia Teresa Groves

Donna Kirsty Finch

Suzanne E Cohen

John Ernest Sims

Jeffrey T McGrew

Dirk E Smith

Karin Von Wachenfeldt

Claire Louise Dobson

Caroline S Russell

Matthew Alexander Sleeman

Marek Z Kubin

Fraser Welsh

Phillip David Monk

Louise Conroy

Per-Olof Fredrik Eriksson

Louise Claire Dobson

Caroline Langham

Fredick Per-Olof Eriksson

David Phillip Monk

Maurice Needham

Karin Von-Wachenfeldt

Patrick Dufner

Caroline Russell

This invention relates to binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1). For example, isolated binding members specific for IL-1R1 which competes with IL-1 and IL-1Ra for binding to IL-1R1 and binds Il-1R1 with a Kof 10 pM or less when measured by Kinexa&#x2122;. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD).

Antibodies to IL-1 R1 and methods of making them

Binding members, especially antibody molecules, for interleukin 17 (IL-17). The binding members are useful for the treatment of disorders associated with interleukin 17 such as rheumatoid arthritis.

Antibodies to IL-17A and uses thereof

Nucleic acid molecule encoding a specific IL-1R1 antibody

Provided herein are IL-18 receptor antigen binding proteins and polynucleotides encoding the same. Expression vectors and host cells comprising the same for production of the antigen binding proteins are also provided. In addition, provided are compositions and methods for diagnosing and treating diseases mediated by IL-18 receptor.

Methods of treatment using IL-18 receptor antigen binding proteins

This invention relates to binding members, especially antibody molecules, for IgE. The binding members are useful for, inter alia, treatment of disorders mediated by IgE including allergies and asthma.

Binding members for IgE molecules

Antibodies to IL-1R1

Growing community of inventors

Cambridge, United Kingdom

Duncan James Cochrane