Merck Sharp + Dohme Corp.

Merck + Co., Inc.

Duncan Edward Shaw

Kevin Dinnell

Timothy Harrison

Brian John Williams

Alan John Nadin

Paul Joseph Oakley

Jose Luis Castro Pineiro

Martin Richard Teall

Ian Churcher

Sonia Kerrad

Andrew Pate Owens

Jason Matthew Elliott

Gregory John Hollingworth

Christopher John Swain

Susannah Williams

Richard Alexander Jelley

Susannah William

Lihu Yang

Janusz Jozef Kulagowski

Kevin Tyler Chapman

Francine Sternfeld

Jeremy Peter Scott

Piotr Antoni Raubo

Christopher Alan Willoughby

Ian Thomas Huscroft

Antony John Davies

Karel Marie Joseph Brands

Joanne Thomson

Steven Michael Hutchins

Karl Richard Gibson

Jason Matthew Elliot

Olivier Dirat

Novel sulphones of Formula I are disclosed: wherein A completes a 4-7 membered ring optionally comprising up to two heteroatoms. The compounds modulate the action of &#x3b3;-secretase and are therefore useful in the treatment or prevention of Alzheimer's disease.

Sulphones which modulate the action of gamma-secretase

Disclosed are sulphones which modulate the action of gamma-secretase. The compounds are useful in the treatment or prevention of Alzheimer's disease.

Sulphones which modulate the action of gamma secretase

Compounds of formula I: inhibit gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease.

Cyclohexyl sulphones as gamma-secretase inhibitors

The present invention relates to compounds of formula (Ia) wherein A, B, n, m, R, R, R, R, R, R, R, R, R, Rand Rare defined herein, and pharmaceutically acceptable salts thereof; the compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

Tetrahydropyran compounds as tachykinin antagonists

Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Cyclic sulfonamides for inhibition of gamma-secretase

Novel sulphones of formula I are disclosed:  The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

Cyclohexyl sulphones

A novel process for preparing cyclohexanone derivatives of formula (I) is described. The products are useful as gamma secretase inhibitors, or as intermediates in the synthesis of other gamma secretase inhibitors.

Synthesis of cyclohexanone derivatives

The present invention relates compounds of the formula (I); wherein R, R, R, R, R, R, R, R, and Rrepresent a variety of substituents; A represents NRor O; B represents a bond, CH, NRor O, wherein one or both hydrogen atoms in said CHmoiety may be replaced with one or both of Rand R, or alternatively, one of the hydrogen atoms in said CHmoiety together with a hydrogen atom from an adjacent carbon are replaced by a double bond; with the proviso that when A is O, then B is NR; n is zero, 1 or 2; and pharmaceutically acceptable salts thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migaine, emesis or postherpetic neuralgia 

Tetrahydropyran derivatives and their use as therapeutic agents

The present invention relates compounds of the formula (I): wherein R, R, R, R, R, R, R, R, Rand Rrepresent a variety of substituents, ring A is a phenyl or pyridyl ring; d is zero, 1 or 2; and pharmaceutically acceptable salts and N-oxides thereof. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia 

Gem-disubstituted cyclohexane derivatives and their use as therapeutic agents

The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and (e); and R, R, R, R, R, R, R, R, R, R, R, R, Rand Rare as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia. 

Cyclohexane derivatives and their use as therapeutic agents

Compounds of formula I: wherein Arand Arare optionally substituted aryl or heteroaryl, L is a bond, &#x2550;CH&#x2014; or &#x2014;(CHR)&#x2014;, and X is SCN, SR, S(O)R, (CRR)SOR, SON(R), SONHCOR, SONHN(R), OSON(R, OS(O)N(R), OSONHCOR, COR, NHCOR, NHCOR, NHCON(R), NHSORor NHSON(R), inhibit the processing of APP by gamma secretase, and hence are useful in treatment of Alzheimer's disease.

Cyclohexyl sulphone derivatives as gamma-secretase inhibitors

Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.

The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R, R, R, R, R, R, R, R, R, R, R, R?17, R, R, Rand Rare as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.

Cyclohexyl derivatives and their use as therapeutic agents

Compounds of formula I:inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.

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Bishops Stortford, United Kingdom

Duncan Edward Shaw