Takeda San Diego, Inc.

Duncan E McRee

Mark Knuth

Robert A Wijnands

Leslie William Tari

Robert J Skene

Ciaran N Cronin

Bi Ching Sang

Ronald V Swanson

Peter R David

Sridhar Govinda Prasad

Douglas R Dougan

David J Hosfield

Ellen Chien

Nikola P Pavletich

Jacek Nowakowski

Sheng Ye

Kathleen Aertgeerts

Devon A Thompson

Frank Von Delft

John Rammelkamp

Enrique Abola

Provided are crystals relating to Aurora/LPL1P-related kinase and its various uses.

Crystallization of aurora/LPL1P-related kinase

Provided are crystals relating to DPPIV and its various uses.

Crystallization of dipeptidyl peptidase IV (DPPIV)

Provided are crystals relating to Cathepsin S and its various uses.

Crystallization of cathepsin S

A method is provided for identifying a search model to use in molecular replacement for determining a structure of a target biomolecule, such as a protein, from X-ray diffraction data, the method comprising: employing computer executable logic to perform multiple molecular replacement searches on X-ray diffraction data of the target biomolecule where a group of different biomolecule structures are used as search models for the multiple molecular replacement searches; and employing computer executable logic to compare solutions from the multiple molecular replacement searches, the comparison producing data from which biomolecule structures can be identified as having superior structural identity with the target biomolecule as compared to the other biomolecule structures in the group.

Determining structures by performing comparisons between molecular replacement results for multiple different biomolecules

Systems and methods are provided for evaluating a crystallization experiment, where a crystallization experiment of a molecule is to X-rays while housed within a container in which the crystallization experiment is performed; and one or more X-ray diffraction patterns from the X-ray exposure are used to evaluate whether crystalline material is present in the crystallization experiment.

Methods and devices for analyzing crystalline content of precipitates and crystals without isolation

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San Diego, CA, United States of America

Duncan E McRee