Delta Pharmaceuticals Ltd.

Glaxo Wellcome Inc.

Smithkline Beecham Corporation

Dulce Garrido Bubacz

Kwen-Jen Chang

Ann O Davis

Robert W McNutt, Jr

Michael J Bishop

David Lee Musso

Marc W Andersen

David John Cowan

Robert Walton McNutt, Jr

Grady Evan Boswell

Robert Carl Andrews

Michael Howard Rabinowitz

Robert William Wiethe

Michael David Gaul

Joseph Howing Chan

Jennifer Badiang Stanford

Mark Allan Collins

Daryl Lynn McDougald

Stephen Andrew Thomson

Jerzy Ryszard Szewczyk

Mark Anthony Collins

Ed Williams McLean

Jennings Franklin Worley, Iii

Iain David Dukes

Andrew James Peat

Robert Anderson Noe

The invention relates to methods of treatment of non insulin dependent diabetes mellitus, antagonists of the delayed rectifier potassium channel Kv2.1, methods of using and preparing the antagonists and assays for identifying such antagonists.

Kv2.1 antagonists

A family of compounds having the general structural formula

Formamide compounds as therapeutic agents

A method for the treatment or prophylaxis of one or more conditions or disorders selected from the group consisting of physiological pain, diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depressioysema, apnea, cognitive disorders and gastrointestinal disorders, comprising administration to a subject in need of such treatment or prophylaxis, of a diarylmethylpiperazine or piperidine opioid compound.

Opioid diarylmethylpiperazines and piperidines

Diarylmethyl piperazine compounds having utility as exogenous receptor combinant species for binding with receptors such as delta, mu, sigma, and/or kappa receptors are disclosed. Compounds of the invention may be employed as conjugates in agonist/antagonist pairs for transductional monitoring and assays of neurotransmitter function, and also variously exhibit therapeutic utility, including mediating analgesia, and possessing utility for the treatment of diarrhea, urinary incontinence, mental illness, drug and alcohol addiction/overdose, lung edema, depression, asthma, emphysema, cough, and apnea, respiratory depression, cognitive disorders, emesis and gastrointestinal disorders.

Opioid compounds

Opioid diarylmethylpiperazines and piperdines

Opioid compounds and methods for making therefor

Opioid compounds and methods for using same

Growing community of inventors

Cary, NC, United States of America

Dulce Garrido Bubacz