Hoffmann-la Roche Inc.

Madrigal Pharmaceuticals, Inc.

F. Hoffmann-la Roche Ag

Duk Soon Choi

Zhongjiang Jia

Ping Wang

Martha Jean Kelly

Charles Howard Reynolds

Ningxin Yan

Urs Schwitter

Robert J Duguid

Ralph Diodone

Lianhe Shu

D Keith Hester, Ii

Anna Chasnoff

Gang Dong

Edwin L Crow

Charles H Reynolds

Martha Kelly

Rebecca Taub

Rudolf Benz

Bharat Patel

D Keith Hester

Keith D Hester

The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR&#x3b2; mutation.

Methods of synthesizing thyroid hormone analogs and polymorphs thereof

Method of synthesizing thyroid hormone analogs and polymorphs thereof

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Flanders, NJ, United States of America

Duk Soon Choi