Anp Technologies, Inc.

US Government As Represented by the Secretary of the Army

Dujie Qin

Ray Yin

Jing Pan

Thomas James Small

Yubei Zhang

De Chen

Yli Remo Vallejo, Jr

Tu-Chen Cheng

H Dupont Durst

Remo Vallejo, Jr

Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.

Hydrophobic molecule-induced branched polymer aggregates and their use

Assays for detecting antibodies to pharmaceutical preparations, food allergens and environmental allergens are described.

Immunogenicity assay

Compositions comprising an oxazoline polymer and optional linkers to carry a variety of molecules.

Oxazoline polymer compositions and use thereof

Modified branched polymers are combined with bioactive agents which are one member of a binding pair for use in an assay.

Polymer conjugate enhanced bioassays

Immunogenicity Assay

Incorporation of modified branched polymers in one or more components of assays enhances sensitivity, specificity or both, providing powerful point of use tests.

A conjugate of a modified randomly branched asymmetric polymer without a core and a member of a binding pair is described. The modified randomly branched asymmetric polymer can contain chain branches, terminal branches or both. The modified randomly branched asymmetric polymer can contain random asymmetric branches or random asymmetric junctions. The binding pair can be an antibody, antigen or a ligand.

Asymmetrically branched polymer conjugates and microarray assays

A conjugate of a modified randomly branched asymmetric polymer without a core and a member of a binding pair is described. The modified randomly branched asymmetric polymer can contain chain branches, terminal branches or both. The modified randomly branched asymmetric polymer can contain random asymmetric branches or random asymmetric junctions. The binding pair can be an antibody, antigen or a ligand. The conjugate includes a drug.

A method of detection comprising a conjugate of a randomly and asymmetrically branched dendritic polymer.

Multi-lateral flow assay strip carrier assembly

Asymmetrically branched polymers are combined with bioactive agents for a variety of purposes including drug delivery and conjugation to one member of a binding pair for use in an assay.

Nanocapsules useful for encapsulating bioactive molecules such as proteins are disclosed. These nanocapsules are comprised of branched or hyperbranched polymers and copolymers and have a core-shell structure forming a pocket volume appropriate for complexing and retaining enzymes and other bioactive molecules. The nanoencapsulated bioactive molecule is stable in extreme temperatures and pH, soluble in aqueous or organic solvents, and can be lyophilized to a dry powder for long-term storage without loss of enzyme activity.

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Wilmington, DE, United States of America

Dujie Qin