Abbott Cardiovascular Systems, Inc.

Abbott Laboratories Corporation

Dudley Shelton Jayasinghe

John E Papp

Mikael Trollsas

Michael H Ngo

Syed F Hossainy

Boris Anukhin

Alexander Nikanorov

Zella Solter

Hung T Nguyen

Gregory Orr

Yongjin Xie

Joshua Smith

Yu-Chun Ku

Dennis R Orosa

Ron Farnbach

Stephen D Pacetti

Kent C B Stalker

Matthew J Gillick

Lewis B Schwartz

Charles Horace Craig

Winnette S McIntosh

Lionel G Hines

A medical device includes a polymer stent (or scaffold) crimped to a catheter balloon. The stent, after being expanded from a crimped state by the balloon, provides a crush recovery of about 90% of its expanded diameter after being pinched or crushed by an amount equal to about 50% of the expanded diameter. The stent has a pattern including a W-shaped or W-V shaped closed cell and links connecting the closed cells.

Balloon expanded polymer stent

A method of crimping a stent is disclosed. The stent includes a minimum crimped diameter such that in the minimum crimped diameter, a pair of stent rings, between which marker support structures reside, do not make contact with the marker support structures. The crimped profile of the stent of the present invention can be as small as the crimped profile of a same stent but without the maker support structures.

Method of crimping stent on catheter delivery assembly

A method of manufacturing a stent is disclosed. The stent includes a minimum crimped diameter such that in the minimum crimped diameter, a pair of stent rings, between which marker support structures reside, do not make contact with the marker support structures. The crimped profile of the stent of the present invention can be as small as the crimped profile of a same stent but without the marker support structures.

Method of making a stent

A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells.

Crush recoverable polymer scaffolds

Methods for making scaffolds for delivery via a balloon catheter are described. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold structure has patterns that include an asymmetric or symmetric closed cell, and links connecting such closed cells.

Processes for making crush recoverable polymer scaffolds

A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 &#x3bc;g/cm. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.

Methods of treatment with drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations

A coated implantable medical device and a method of coating an implantable medical device is disclosed, the method includes applying a composition onto the device and drying the composition at elevated temperature in an environment having increased relative humidity. A pre-screening method for a manufacturing lot of coated stents to determine the number of drug coating layers for a desired drug release rate is disclosed. The method including coating and testing small groups of stents, and applying the results of the tests to determine the number of drug coating layers to apply to the manufacturing lot of stents.

Coated stent and method of making the same

Medical devices comprising nanobeads encapsulating one or more bioactive agents and methods of use thereof are provided.

Nanobead releasing medical devices

Growing community of inventors

Murrieta, CA, United States of America

Dudley Shelton Jayasinghe