Monsanto Company

G.d. Searle & Company

Dudley E McMackins

James P Coleman

Richard C Hallcher

Charles F Hobbs

Foe S Tjoeng

Mihaly V Toth

Steven P Adams

Thomas Edward Rogers

Masateru Miyano

Joseph Gerace Rico

Philippe R Bovy

Steven R Auvil

Robert B Garland

Jeffery A Zablocki

Charles R Penquite

Novel urea derivatives and pharmaceutical compositions thereof are provided which inhibit platelet aggregation.

Urea derivatives useful as platelet aggregation inhibitors

Novel urea compounds are provided which inhibit platelet aggregation as well as pharmaceutical compositions and methods of using said compounds.

Novel urea derivatives are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.

This invention relates to having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidines derivatives.

Peptide mimetic compounds useful as platelet aggregation inhibitors

Butadiene and acetic acid are reacted with metal ion oxidant to prepare acetoxyhexenoic acids which are then converted to sorbic acid.

Sorbic acid process

This disclosure concerns acyloxyhexenoic acids and their salts with the acids being produced by reaction of butadiene and acetic acid with metal salt oxidants in a process involving electrolytic regeneration of the metal oxidants during the reaction. Iosmeric acetoxyhexenoic acids produced can be readily converted to sorbic acid, and antimicrobial and preservative uses for the acids are also disclosed.

Acyloxyalkenoic acids and process therefor

In processes for reacting acetic acid with butadiene in solvent to prepare acetoxyhexenoic acid and .gamma.-vinyl-.gamma.-butyrolactone, involving electrolytic regeneration of a metal ion oxidant such as trivalent manganese, the product separation is facilitated by using low melting electrolyte salts and separating product from salts maintained in a molten state.

Product separation from electrolyte salts maintained in molten state

Butadiene and acetic acid are reacted with a metal salt oxidant in molten salt medium to form .gamma.-vinyl-.gamma.-butyrolactone. The process includes electrolytic regeneration of the oxidant and provides a simple reaction system which permits product recovery and reactant recycle without extensive solvent handling. A high surface area reactor can be employed.

Production of lactone in molten salt electrolysis

In the process of preparing acetoxyhexenoic acids from butadiene, acetic acid and acetic anhydride, selectivity is improved by converting the acetoxyhexenoic acids to .gamma.-vinyl-.gamma.-butyrolactone before isolation. Copper and platinum are useful catalysts in the conversion.

Synthesis of .gamma.-vinyl-.gamma.-butyrolactone from acetoxyhexenoic

Acyloxyhexenoic acids are converted to .gamma.-vinyl-.gamma.-butyrolactone.

Lactone process

Acyloxyhexenoic acids are produced by reaction of butadiene and acetic acid with metal salt oxidants in a process involving electrolytic regeneration of the metal oxidants during the reaction.

A process for the asymmetric synthesis of amines which comprises the amination of a conjugated diene having from 4 to about 20 carbon atoms in the presence of a catalyst system comprising a palladium compound and an optically active phosphine ligand containing at least two phosphorus atoms.

Asymmetric amination of 1,3-dienes

N-(alkadienyl)amines are produced at a rapid rate and in high yield by the reaction of conjugated dienes with ammonia and amines in a hydroxylic solvent using a catalyst system comprising a palladium compound co-catalyzed with a phosphonite ligand.

Production of unsaturated amines

Short chain, unsaturated primary and secondary amines are prepared by reaction of ammonia and conjugated dienes in a primary or secondary aliphatic alcohol solvent medium and in the presence of a catalyst system comprising a palladium compound co-catalyzed with a phosphine ligand containing 2 to 4 phosphorus atoms.

Production of primary and secondary amines by reaction of ammonia with

In the process of producing N-(alkadienyl)amines by the amination of conjugated dienes in a hydroxylic solvent medium in the presence of a catalyst comprising a palladium compound co-catalyzed with a phosphonite ligand, the improvement in which the phosphonite ligand is polymerized with polyvinyl alcohol whereby the catalyst can be readily separated from the liquid rection products.

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St. Charles, MO, United States of America

Dudley E McMackins