Erasmus University Medical Centre

Erasmus University Medical Center

Harbour Biomed (shanghai) Co., Ltd.

Erasmus University Medical Center Rotterdam

Craig, Roger Kingdon

Harbour Biomed Co., Ltd

Dubravka Drabek

Roger Kingdon Craig

Franklin Gerardus Grosveld

Richard Wilhelm Janssens

Richard Willhelm Janssens

Yun He

Frank Grosveld

Ernie De Boer

Rick Janssens

Marinus (Rien) Van Haperen

Yiping Rong

Jiuqiao Zhao

Xin Gan

Tao Chen

Yuqiang Shen

Franklin Geradus Grosveld

Marinus Van Haperen

Disclosed are isolated monoclonal antibodies, comprising a CD152-binding domain, wherein the antibodies bind specifically to human CD152. Methods of making and using the antibodies to treat diseases including cancers and autoimmune diseases are also provided.

Antibodies binding CTLA-4 and uses thereof

The present invention relates to a method of generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge.

Methods of making heavy chain only antibodies using transgenic animals

The present invention provides a high affinity, antigen-specific, soluble heavy chain-only antibody which: lacks hallmark camelid-related amino acid substitutions and has FR2 substitutions which are not found in antibodies which comprise heavy and light chain; shows increased net hydrophobicity within CDR1 and an increased number of charged amino acids present in CDR3; and comprises one or more amino acid substitutions within the framework &#x3b2;-pleated sheet leading to increased net hydrophobicity within FR1 and increased number of charged amino acids present in FR3. Also provided are VH domains having the same properties, gene segments for their production, methods for their production, transgenic animals and uses of the antibody of the VH domains in therapy.

Soluble heavy-chain only antibodies

The present invention relates to the manufacture of a diverse repertoire of functional heavy chain-only antibodies that undergo affinity maturation, and uses thereof. The invention also relates to the manufacture and use of a diverse repertoire of class-specific heavy chain-only antibodies and to the manufacture and use of multivalent polypeptide complexes with antibody heavy chain functionality, preferably antibody heavy chain binding functionality, constant region effector activity and, optionally, additional effector functions. The present invention also relates to a method of generation of fully functional heavy chain-only antibodies in transgenic mice in response to antigen challenge. In particular, the present invention relates to a method for the generation of human antigen-specific, high affinity, heavy chain-only antibodies of any class, or mixture of classes and the isolation and expression of fully functional VH antigen-binding domains.

Binding molecules

Soluble 'heavy-chain only' antibodies

Growing community of inventors

Rotterdam, Netherlands

Dubravka Drabek