Washington University

Duanwen Shen

Samuel I Achilefu

Kexian Liang

Rui Tang

Partha Karmakar

Baogang Xu

Christopher Egbulefu

Gail Sudlow

Avik Som

Provided herein is a pharmaceutical composition comprising an effective amount of cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Lys-OH (LS301), cypate-Cyclo(Cys-Gly-Arg-Asp-Ser-Pro-Cys)-Tyr-OH (LS838) or pharmaceutically acceptable salts thereof, wherein each amino acid residue is independently in a D or L configuration; a divalent metal ion; and a pharmaceutically acceptable carrier. Further provided are lyophilized products comprising a dye-conjugate and m methods for identifying compromised and for binding phosphorylated annexin A2 (pANXA2) protein in a biological sample using a composition described herein.

Near infrared fluorescent dyes, formulations and related methods

Growing community of inventors

St. Louis, MO, United States of America

Duanwen Shen