Agency for Science, Technology and Research

National University of Singapore

Duanting Zhai

Young-Tae Chang

Nam-Young Kang

Seong-Wook Yun

Sung-Jin Park

Marc Vendrell Escobar

Sung-Chan Lee

Yun-Mi Jeong

Yogeswari Chandran

Kit Mun Cheryl Leong

The present invention is directed to a novel family of fluorophores based on the BODIPY scaffold, and methods for their synthesis. The BODIPY-based fluorophores disclosed herein are used for the selective visualization of cells that exist in the M-phase of the cell cycle. The present invention further relates to methods for the image-based monitoring of mitotic progression in live cells.

Fluorescent cell cycle probe having M-phase specificity

The present invention discloses a series of alkylamino BODIPY dyes, methods for preparing a library of alkyl-amino BODIPY dyes via solid-phase synthesis, and the use of the alkyl-amino BODIPY dyes as fluorescent sensors for protein detection, cell imaging and cytometry applications, and staining of certain cell line.

Alkylamino BODIPY dyes as selective fluorescent probes for proteins and mouse embryonic stem cells

The present invention is directed to a fluorescence compound represented by structural Formula (I), with specificity to neural stem cells: I or a pharmaceutically acceptable salt thereof. The variables for structural Formula (I) are defined herein. Also described are methods for detection of neural stem cells, comprising using a compound of structural Formula (I) or pharmaceutically acceptable salts thereof. Compounds of structural Formula (I) can detect and separate neural stem cells without immunostaining, providing a much shorter and more convenient method for detection of neural stem cells. 

BODIPY structure fluorescence dye for neural stem cell probe

Growing community of inventors

Singapore, Singapore

Duanting Zhai