Shenzhen Salubris Pharmaceuticals Co. Ltd.

Tianjin University

Duanming Tan

Jun Ou

Baohong Hou

Junbo Gong

Qiuxiang Yin

Jingkang Wang

Qi Wang

Liting Liao

Ziyuan Di

Guanhao Ye

Shui Bu

Xiaopeng Song

Disclosed are polymorph of allisartan isoproxil and a pharmaceutical composition thereof. The polymorph is non-electrostatic, highly flowable and highly stable, and can be used for treating hypertension and complications thereof.

Allisartan isoproxil polymorph, its preparation method and pharmaceutical

This invention provides a new preparation method of Clopidogrel Hydrogen Sulfate spherical crystal form I, using single 2-butanol as solvent, controlling the concentration, addition way and addition speed of sulfuric acid used to salify to shorten the process time, thus separating out Clopidogrel Hydrogen Sulfate from solution system stably with spherality. And the Clopidogrel Hydrogen Sulfate obtained complies with the requirements of the follow-up process on residual solvent, bulk density and mobility.

Method for preparing spherical Clopidogrel Hydrogen Sulfate polymorph I

The present invention relates to an amorphous allisartan isoproxil which is an angiotensin II receptor blocker with good flowability and a large bulk density and with no obvious electrostatic phenomenon; the find of the amorphous allisartan isoproxil can effectively reduce the generation of dust pollution during the production, thereby providing convenience the production of allisartan isoproxil. The present invention also relates to a pharmaceutical composition containing the amorphous allisartan isoproxil. The pharmaceutical composition is highly stable, and allisartan isoproxil formulation prepared from the pharmaceutical composition can effectively ensure the quality of the drug.

Amorphous allisartan isoproxil, preparation method therefor, and pharmaceutical composition containing amorphous allisartan isoproxil

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Shenzhen, China

Duanming Tan