Alliance Pharmaceutical Corp.

Duane J Roth

Nicholas Simon Faithfull

Peter E Keipert

Jean G Riess

Ronald M Hopkins

Thomas F Zuck

A method for treating conditions associated with ischemia or infarct is disclosed which includes the steps of administering a biocompatible non-blood oxygen carrier while monitoring one or more oxygenation indices to maintain oxygenation of the patient's tissues at or above a predetermined level.

Method for the treatment of organ ischemia or infarct comprising

A method for hemodiluting a patient is disclosed which includes the steps of administering a biocompatible oxygen carrier in conjunction with surgery or organ ischemia or infarct while assessing the patient's PvO.sub.2 or other oxygenation indices, and administering to the patient additional oxygen carrier or autologous blood in response to the PvO.sub.2 value if necessary to maintain the PvO.sub.2 at or above the desired level.

Method of hemodilution facilitated by monitoring oxygenation status

A method for facilitating autologous blood use by a patient facing a loss of blood, comprising the steps of removing and preferably storing a portion of the patient's blood, intravenously administering a biocompatible liquid in sufficient quantity to substantially maintain the patient's hemodynamic stability, wherein the liquid comprises an effective oxygen-delivery enhancing amount of a biocompatible synthetic oxygen carrier, after which the patient undergoes a loss of blood, and then readministering blood to the patient, preferably the stored blood. In one embodiment, the biocompatible liquid further comprises a hemodiluent and the hemodiluent is administered separately from the oxygen carrier.

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La Jolla, CA, United States of America

Duane J Roth