Imec Vzw

Katholieke Universiteit Leuven, Ku Leuven R&d

Imec

Katholieke Universiteit Leuven

Dries Braeken

Veerle Reumers

Richard Stahl

Alexandru Andrei

Peter Peumans

Liesbet Lagae

Andy Lambrechts

Geert Vanmeerbeeck

Veronique Rochus

Abdulkadir Yurt

Carolina Mora Lopez

Roeland Huys

Wolfgang Eberle

Carmen Bartic

Luis Diego Leon Hoffman

Silke Musa

Danielle Rand

Thomas Pauwelyn

Andrea Firrincieli

Zhenxiang Luo

Aaron Delahanty

Bart Weekers

Liesbeth Micholt

Dimiter Prodanov

A semiconductor cell culture device for three-dimensional cell culture comprises: a semiconductor material layer in which a cell culture portion of semiconductor material is defined, wherein the cell culture portion defines an area within the semiconductor material layer surrounded by semiconductor material, wherein the cell culture portion comprises a mesh structure having island structures being interconnected by bridge structures and defining through-pores between the island structures allowing for selective transport of cell constructs, cellular components, proteins or other large molecules through the semiconductor material layer and on opposite sides of the cell culture portion in the semiconductor material layer, and a supporting structure connected to the cell culture portion.

Semiconductor cell culture device and a system for three-dimensional cell culture

A method for three-dimensional imaging of a sample () comprises: receiving () interference patterns () acquired using light-detecting elements (), wherein each interference pattern () is formed by scattered light from the sample () and non-scattered light from a light source (), wherein the interference patterns () are acquired using different angles between the sample () and the light source (); performing digital holographic reconstruction applying an iterative algorithm to change a three-dimensional scattering potential of the sample () to improve a difference between the received interference patterns () and predicted interference patterns based on the three-dimensional scattering potential; wherein the iterative algorithm reduces a sum of a data fidelity term and a non-differentiable regularization term and wherein the iterative algorithm includes a forward-backward splitting method alternating between forward gradient descent () on the data fidelity term and backward gradient descent () on the regularization term.

Lensfree method for imaging biological samples in three dimensions

A device for analysis of cells comprises: an integrated circuit arrangement on a substrate; a dielectric layer formed above the integrated circuit arrangement; a microelectrode array layer formed above the dielectric layer, said microelectrode array layer comprising a plurality of individual electrodes, wherein each electrode is connected to the integrated circuit arrangement through a via in the dielectric layer; and wherein a plurality of longitudinal trenches in the dielectric layer and the microelectrode array layer are for stimulating cell growth on a surface of the device

Device for analysis of cells and a method for manufacturing of a device

The present disclosure relates to devices and methods configured to perform drug screening on cells. At least one embodiment relates to a lens-free device for performing drug screening on cells. The lens-free device includes a substrate having a surface. The lens-free device also includes a light source positioned to illuminate the cells, when present, on the substrate surface with a light wave. The lens-free device further includes a sensor positioned to detect an optical signal caused by illuminating the cells. The substrate surface includes a microelectrode array for sensing an electrophysiological signal from the cells.

Method and device for drug screening

In an aspect of the disclosure, a stimulation device includes a probe attached to a first support. The probe includes at least one grating coupler for coupling light into the probe. The device further includes at least one optical source for providing an optical stimulation signal mounted on a second support, and at least one means for detachably attaching the first support to the second support. The position of the at least one optical source is aligned with the position of the at least one grating coupler to allow light emitted from the at least one optical source to be received by the at least one grating coupler.

Optical stimulation device

The electronic device for sensing and/or actuating comprises a device surface to which an biological cell () is applied, further comprising a sensor and/or an actuator (), and an access channel () with a channel port (), said channel port being located in said surface. The access channel () is designed such that the biological cell () can enter the access channel () to thereby provide access to the sensor (). Particularly the cell () forms a protruding portion () by entering the access channel (), which portion is sensed. The access channel () may be provided with a specific sensor port at which the sensor () is present. The device may be used for sensing or actuating biological cells, such as neurons, for instance in electroporation treatments.

Microneedle

The invention relates to a sensor comprising a sensing layer and a surface layer, wherein said surface layer comprises, a first region suitable for adherent growth of cells, and a second region, adjacent to said second layer, suitable for the attachment of proteins, wherein the first and second region are in contact with the sensing layer.

Cell-enzyme based biosensors

Growing community of inventors

Overpelt, Belgium

Dries Braeken