Know Bio, LLC

Duke University

Drew Folk

Ryan Gerald Anderson

Mona Jasmine Rosales Ahonen

John Kelly Simons

Rebecca McDonald

Katherine J Franz

Rebecca Anthouard Mcdonald

Several embodiments of NO releasing compounds are disclosed. In some embodiments, the structures are covalently modified to store and release nitric oxide. Some embodiments pertain to methods of making and use of these structures. The compounds may be tailored to release nitric oxide in a controlled manner and can be useful, for example, for treating or preventing microbial infections, or reducing the microbial load of a microbial infection.

Nitric oxide-releasing antibacterial compounds, formulations, and methods pertaining thereto

Molecular probes are provided for use in fluorescence microscopy procedures for monitoring beta-secretase enzyme (BACE) activity in living cells and organisms. The probes may be useful for monitoring Alzheimer's Disease-associated BACE in living cells. By fluorescing when hydrolyzed by BACE, the probes can allow for real-time spatial and temporal assessment of enzymatic activity without the need for mutated cell lines or antibodies. The molecular probes may also be used to screen libraries of potential BACE inhibitors or evaluate how external stimuli affect BACE activity.

Compositions and methods for imaging beta-secretase activity in living cells and organisms

Growing community of inventors

Durham, NC, United States of America

Drew Folk