The Broad Institute, Inc.

Harvard College

Dana-farber-cancer Institute Inc.

The Brigham and Women's Hospital, Inc.

Howard Hughes Medical Institute

Drew Adams

Matthew Meyerson

Mohamed Abazeed

Stuart L Schreiber

Mingji Dai

Zarko Boskovic

Mahmud Mustaqim Hussain

The invention provides for the use of radiation sensitizing agents in combination with radiation for the treatment of neoplasia, methods for the identification of genotype-specific radiation sensitizing agents, and methods of identifying patients who could benefit from therapy with a genotype-specific radiation sensitizing agent.

Compositions and methods for sensitizing a neoplastic cell to radiation

Compounds including various oligomers of piperlongumine and/or piperlongumine analogues as well as certain piperlongumine analogues that exhibit improved toxicity to cancer cells are disclosed. Also provided are compositions that comprise the compounds, methods of making compositions comprising the compounds, methods of making the compounds, and the use of compounds in methods for treating cancer.

Compounds, compositions, and methods for cancer therapy

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Cambridge, MA, United States of America

Drew Adams