Iterion Therapeutics, Inc.

Centrexion Therapeutics Corporation

United Therapeutics Corporation

Drazen Ostovic

Gary Fred Musso

James N Campbell

Gowri Sukumar

Peter Noymer

Randall Stevens

Michael Laird Hurrey

Peter D Hanson

Formulations of tegavivint, methods of making such formulations, and methods of treatment of cancer by administering the formulations.

Formulations of tegavivint

The present invention relates to crystalline forms of (9E,10E)-2,7-bis((3,5-dimethylpiperidin-1-yl)sulfonyl)anthracene-9,10-dione dioxime, pharmaceutical compositions comprising the crystalline form, processes for preparing the crystalline form and methods of use therefore.

Crystalline form of tegavivint, method of preparation, and use thereof

Lyophilized formulations of tegavivint, methods of making such formulations, and methods of treatment of cancer by administering the formulations.

Lyophilized formulations of tegavivint

The invention provides stable, aqueous capsaicin injectable formulations, a unit dose containing such injectable formulations, medical kits, and methods for using such injectable formulations and unit doses to treat patients suffering from pain, such as osteoarthritic knee pain. The stable, aqueous capsaicin injectable formulations may contain, for example, capsaicin, a solubilizing agent (e.g., a polyethylene glycol ester of a (C-C) hydroxyalkanoic acid), an antioxidant, and water.

Stable aqueous capsaicin injectable formulations and medical uses thereof

This invention describes compositions comprising at least 75 mg/mL of solubilized otherwise poorly soluble drug in an aqueous environment, wherein the composition further comprises a combination of 3 or more acids. Methods of providing analgesia, anti-pyretic effects or reducing pain in a subject presenting with a pain condition, and methods of reducing administration site irritation, inflammation or a combination thereof in a subject presenting with a pain condition, comprising the steps of administering such compositions and infusion pumps containing such compositions are also described.

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Redwood City, CA, United States of America

Drazen Ostovic