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Zap Surgical Systems, Inc.

Doyle John Borchers, Iii

M Bret Schneider

John R Adler

Michele Borchers, Legal Representative

Radiosurgical techniques and systems treat behavioral disorders (such as depression, Obsessive-Compulsive Disorder ('OCD'), addiction, hyperphagia, and the like) by directing radiation from outside the patient toward a target tissue within the patient's brain, typically without imposing surgical trauma. The target will often be included in a neural circuit associated with the behavioral disorder. A cellularly sub-lethal dose of the radiation may be applied and the radiation can mitigate the behavioral disorder, obesity, or the like, by modulating the level of neural activity within the target and in associated tissues. Hypersensitive and/or hyperactive neuronal tissue may be targeted, with the radiation downwardly modulating hyperactive neuronal activity. By down-regulating the activity of a target that normally exerts negative feedback or a limiting effect on a relevant neural circuit, the activity of the circuit may be increased.

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Palo Alto, CA, United States of America

Doyle John Borchers, Iii