Transgenomic, Inc.

Phynexus, Inc.

Other

Sarasep, Inc.

Cetac Technologies, Inc.

Vosbio, Inc.

Douglas T Gjerde

Paul D Taylor

Robert M Haefele

Christopher P Hanna

David W Togami

Chris Suh

Lee Hoang

Guenther Bonn

Ronald Jones

Allen Burge

Mark J Abel

Christopher T Hanna

Carrie Loan Kim Huynh

David P Hornby

Christian Wolfgang Huck

Kimberly A Lamb

Thomas Jakschitz

Jonathan Michael Grambow

Karl H Hecker

John E Sutton

Alexander I Kuklin

Benjamin L Legendre, Jr

Robert M Hae Fele

Jennifer E Grant

Mathias Rainer

Raquel R Roque

Daniel R Wiederin

Günther Bonn

Leon Yengoyan

Rania Bakry

Matthias Rainer

Gunther Bonn

James V Benson

Arezou Azarani

Maryam Matin

Satyajit Kar

Gunther Stecher

Laura Bunnel

Alexander Bonn

Bernhard Maerk

Jeffrey L Sklar

Harald Sonderegger

Isabel Feuerstein

David Peter Joseph Hornby

Fabio Polato

Guenther Stecher

Alezander I Kuklin

This invention employs solid phase extraction media and column methods to apply external and internal standards and compounds. Analytical standard or compounds including PFAS are adsorbed to a solid phase extraction media and are stored indefinitely. The standards or compounds remain stable on the solid phase extraction media without decomposing. The standards or compounds may be removed from the solid phase extraction media with an elution solvent or reagent.

Columns and methods of use for analytical standards and compounds

Methods, devices and kits for sampling, releasing and stabilizing nucleic acid, including RNA and DNA, from virus, bacteria yeast and other cells is described. The released and stabilized nucleic acid may be analyzed and quantified without further sample preparation at the point of care or may be transported to a testing laboratory by shipment and analyzed directly. The nucleic acid, which can be RNA, remains safe and stable so that shipping by normal means including government postal service may be used. In addition, the RNA sample remains stable so that analysis can be performed immediately after receipt of sample or after storage for days, weeks or months. Storage may be at room or ambient temperature or cooler temperatures. The sampling apparatus used to acquire samples can interface with nucleic detection and measurement instrumentation including high throughput, parallel processing instruments.

Methods, devices and kits for preparing nucleic acid samples for storage and analysis

This invention employs columns and methods to apply external and internal standards and compounds. Analytical standard or compounds are adsorbed to a solid phase extraction media and are stored indefinitely. The standards or compounds remain stable on the solid phase extraction media without decomposing. The standards or compounds may be removed from the solid phase extraction media with a solvent.

The invention provides columns (including pipette tip columns) and automated methods for the purification of nucleic acids including plasmids. Nucleic acids can be purified from unclarified, clarified or partially-clarified cell lysates that contain cell debris. The columns typically include a bed of medium positioned above a bottom frit and with an optional top frit. Plasmid preparation scales include miniprep, midiprep, maxiprep, megaprep and gigaprep.

Devices and methods for plasmid purification

This invention relates to devices and methods for purifying, detecting and using biological cells. A variety of cell types including viable tumor, stem, immune and sperm cells can be purified from a complex biological sample using a column, including a pipette tip column. Methods of the invention can aid research, diagnosis and treatment of cancer. Purified viable cells can be detected on the column or eluted from the column and detected. Cells on a column can be used as a stationary phase for liquid chromatography. Cells may be removed, recovered and analyzed.

Isolation, detection and use of biological cells

Columns for isolation, detection and use of biological cells

This invention relates to devices and methods for purifying biological cells. For example, viable tumor, stem, immune and sperm cells can be purified from a complex biological sample using a pipette tip column. Methods of the invention can aid research, diagnosis and treatment of cancer.

Methods for purifying biological cells

The invention provides pipette tip columns and automated methods for the purification of nucleic acids including plasmids. Nucleic acids can be purified from unclarified, clarified or partially-clarified cell lysates that contain cell debris. The columns typically include a bed of medium positioned in the pipette tip column, above a bottom frit and with an optional top frit. Plasmid preparation scales include miniprep, midiprep, maxiprep, megaprep and gigaprep.

Methods and devices for nucleic acid purification

Devices and methods for purification, detection and use of biological cells

Growing community of inventors

Saratoga, CA, United States of America

Douglas T Gjerde