Medtronic Ardian Luxembourg S.a.r.l.

Forsight Vision4, Inc.

Ardian, Inc.

Nexisvision, Inc.

Forsight Vision5, Inc.

Twelve, Inc.

Emphasys Medical, Inc.

Journey1, Inc.

Cabochon Aesthetics, Inc.

Pulmonx Corporation

Intervene, Inc.

Medtronic Ireland Manufacturing Unlimited Company

Medtronic Adrian Luxembourg S.a.r.l.

Other

Forsight Labs, LLC

Douglas Sutton

Hanson Gifford

Mark Gelfand

Howard R Levin

Mark E Deem

Denise Marie Zarins

Eugene De Juan, Jr

Yair Alster

Cary J Reich

K Angela Macfarlane

Hanson S Gifford, Iii

Erik Thai

Denise M Demarais

Jose D Alejandro

Randolph E Campbell

Michael Barrett

Benjamin J Clark

Stephen A Boyd

Dean F Carson

Kathleen Cogan Farinas

Matt Clarke

Brian Levy

Ronald G French

James I Fann

John H Morriss

Michael Luna

Jean-Pierre Dueri

Matt McLean

Robert George

Neil Chand Barman

Darin Charles Gittings

Mariel Fabro

Christopher Scott Jones

John Anthony Scholl

Fletcher T Wilson

Jeffry J Grainger

Michael J Hendricksen

Signe R Erickson

Antony Jonathan Fields

Darren G Doud

Richard L Lindstrom

Alan R Rapacki

Ronald Ray Hundertmark

Peter M Wilson

Nicolas Zadno

Matthew McLean

Andrew Lewis Johnston

Omer Rafaeli

David R Tholfsen

Sunmi Chew

David Sierra

Ashley Tuan

Doug Rimer

Enrique Barragan

Garrett Marc Schwab

Roger Osborne

Steven M Chamow

K Angela MacFarlane

Benjamin Kahn Cline

Janelle Chang

Alexander J Gould

Eugene De Juan

Christina Skieller

John G McCutcheon

Neil S Zimmerman

David Batten

Mike Barrett

Greg Stine

Jr De Eugene

Gaurav Krishnamurthy

Rhunjay James Yu

Jose Gonzalez

Robert O'Grady

Omer Refaeli

Jeffrey J Dolin

R James Yu

Matt Mclean

Jeffrey J Grainger

James L Fann

Cassandra Orth

Jeffrey Martin

Darrin Gittings

Hanson S Giffor, Iii

Eugene Jr De Juan

Hanson S Gifford

Alexander Julian Gould

Hanson Iii Gifford

Denise Demarais

Hanson S Gifford Iii

Angela K Macfarlane

Delivery systems for implanting cardiac valve repair devices are disclosed herein. In some embodiments, a delivery system includes a delivery catheter, a hub shaft extending through the delivery catheter, and a core shaft extending through the hub shaft. The delivery catheter is configured to hold a valve repair device in a compressed configuration. The hub shaft includes a hub configured to releasably engage a first portion of the valve repair device, and the core shaft includes a plug configured to releasably engage a second portion of the valve repair device. When the valve repair device is unsheathed from the delivery catheter, the hub shaft and the core shaft are independently movable to axially elongate/compress the valve repair device. When the valve repair device is properly positioned, the hub can be actuated to release the first portion of the valve repair device, and the plug can be actuated to release the second portion of the valve repair device.

Delivery systems for cardiac valve devices, and associated methods of operation

Described here are methods and systems for the manipulation of ovarian tissues. The methods and systems may be used in the treatment of polycystic ovary syndrome (PCOS). The systems and methods may be useful in the treatment of infertility associated with PCOS.

Methods and systems for the treatment of polycystic ovary syndrome

A heart valve repair device, comprising an atrial-fixation member having an expandable mesh configured to have oval or circular shape in a deployed configuration, the atrial-fixation member defining a central lumen; and a baffle extending from a portion of the atrial-fixation member, the baffle having an anterior portion with a smooth, atraumatic surface configured to coapt with at least a portion of one or more native leaflets of a native heart valve, a posterior portion configured to engage and displace at least a portion of another native leaflet of the native heart valve, wherein the baffle extends radially inward from the atrial-fixation member into the central lumen to approximate a closed position of the displaced native leaflet.

Prosthetic leaflet device

Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Bilateral renal neuromodulation

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Methods and apparatus for renal neuromodulation

Medical systems, devices and methods for creation of autologous tissue valves within a mammalian body are disclosed. One example of a device for creating a valve flap from a vessel wall includes an elongate tubular structure having a proximal portion and a distal portion and a longitudinal axis; a first lumen having a first exit port located on the distal portion of the elongate tubular structure; a second lumen having a second exit port located on the distal portion of the elongate tubular structure; a recessed distal surface on the distal portion of the elongate tubular structure, wherein the recessed distal surface is located distally to the first exit port; and an open trough on the recessed distal surface extending longitudinally from the first exit port.

Systems and methods for endoluminal valve creation

A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. A plurality of interconnecting channels can extend from the first side to the second side so as to connect a first a plurality of openings on the first side with a second plurality of openings on the second side.

Posterior segment drug delivery

Prosthetic heart valve devices for percutaneous replacement of native heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having a first portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a valve support coupled to a second portion of the anchoring member, configured to support a prosthetic valve and having a cross-sectional shape. In some embodiments, the first portion of the anchoring member is mechanically isolated from the valve support such that the cross-sectional shape of the valve support remains sufficiently stable that the prosthetic valve remains competent when the anchoring member is deformed in the non-circular shape.

Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods

Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

Methods and apparatus for bilateral renal neuromodulation

A comfortable insert comprises a retention structure sized for placement under the eyelids and along at least a portion of conjunctival sac of the upper and lower lids of the eye. The retention structure resists deflection when placed in the conjunctival sac of the eye and to guide the insert along the sac when the eye moves. The retention structure can be configured in many ways to provide the resistance to deflection and may comprise a hoop strength so as to urge the retention structure outward and inhibit movement of the retention structure toward the cornea. The insert may move rotationally with deflection along the conjunctival sac, and may comprise a retention structure having a cross sectional dimension sized to fit within folds of the conjunctiva. The insert may comprise a release mechanism and therapeutic agent to release therapeutic amounts of the therapeutic agent for an extended time.

Ocular insert apparatus and methods

Growing community of inventors

Pacifica, CA, United States of America

Douglas Sutton