Leland Stanford Junior University

Other

Enodis Corporation

Garland Commercial Industries, LLC

Lincoln Foodservice Products, Inc.

The Frymaster Corporation

Aravive Biologics, Inc.

Torque Therapeutics, Inc.

Absolute Stealth Ltd.

Gas Research Institute

Cleveland Range, LLC

The Garland Group

Merco/savory, LLC

Douglas Scott Jones

Jennifer R Cochran

David W Harter

Mihalis S Kariolis

Roberto Nevarez

Ryan J Stephens

Amato J Giaccia

Yu Rebecca Miao

Katherine Cynthia Fuh

Erinn Bruno Rankin

Jan Claesson

William Day

Malcolm Reay

Adam Silverman

Niv Papo

Gerald W Sank

Ping-Chuan Tsai

William J Day, Jr

David H McFadden

Ronald J Forni

Ulrik Bjerl Nielsen

Thomas Lars Andresen

James Timothy Cole

Donald E Fritzsche

Jerry Sank

Henry Preston Hutson, Jr

Susan Hershenson

Michael Feldhaus

Robert C Franklin

James M Cobb

Gorm Bressner

Raymond Tabibiazar

Robert J Wenzel

Paulo Jorge Rosa

Dave Harter

Christopher John Reis

Paul R Molloy

Patrick A Lynch

Gregory L Good

Paul Molloy

Derek Allen Walz

James Andrew Rakestraw

Ferdinando Pucci

Jonathan D Nardozzi

Jesse Lyons

De-Kuan Chang

Michael Robin Sykes

Patrick O'Connor

Steven Paul Everett, Jr

P Andrew Tyler

Jan Cleasson

Roberto Navarez

Paul S Molloy

The present disclosure presents a general approach to engineering existing protein-protein interactions through domain addition and evolution. The disclosure teaches the creation of novel fusion proteins that include knottin peptides where a portion of the knottin peptide is replaced with a sequence that has been created for binding to a particular target. Such fusion proteins can also be bispecific or multi specific in that they can bind to and/or inhibit two or more receptors or receptor ligands. Knottins may be fused with an existing ligand (or receptor) as a general platform tor increasing the affinity of a ligand-receptor interaction or for creating a multi specific protein. In addition, the fusion proteins may comprise a knottin peptide fused to another protein where the other protein facilitates proper expression and folding of the knottin.

Fusion proteins comprising an engineered knottin peptide and uses thereof

The present disclosure features, at least in part, methods for conserving cell function, e.g., immune cell function, e.g., after one or more cycles of freezing and/or thawing the nucleated cell. In embodiments, the methods comprise contacting an immune cell with a protein nanoparticle comprising an IL-15 complex.

Methods and compositions for promoting immune cell function

Immunostimulatory fusion molecules that include an immune cell targeting moiety and a cytokine molecule, pharmaceutical and formulations thereof, and methods of using and making the same, are disclosed.

T cells surface-loaded with immunostimulatory fusion molecules and uses thereof

The combined battery jumper cable with wrench is configured for use with a vehicle. The combined battery jumper cable with wrench forms an electric termination that attaches a cable to a terminal post of the vehicle battery. The combined battery jumper cable with wrench forms a ratchet that is used to attach an electrical terminal of the vehicle to the terminal post of the vehicle battery. The combined battery jumper cable with wrench includes a working head, a transfer mount, and a motive structure. The transfer mount attaches the motive structure to the working head. The working head is the working element of the tool. The motive structure transfer externally provided energy to the working head through the transfer mount. The motive structure removably attaches to the transfer mount.

Combined battery jumper cable and wrench

The present disclosure provides a grill having a movable upper platen and a lower platen, the latter of which holds food products that are cooked by between the platens. The upper platen has a platen arm, locking drive, and locking pin connected thereto. An actuator, drive shaft, and drive shaft head are operably connected to the platen arm. During operation of the grill, the locking drive drives the locking pin into the drive shaft head, holding the upper platen parallel to the lower platen, even when greater downward pressure is applied by the actuator than the weight of the upper platen. In prior art devices, applying this kind of pressure would cause the upper platen to become nonparallel to the lower platen, causing uneven cooking. Locking the upper platen horizontally ensures that the upper platen will not go out of horizontal level when it comes into contact with food products on the lower platen.

Two-sided cooking device with upper platen position locking mechanism for high compression precision positioning controlled cooking

Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.

Modified AXL peptides and their use in inhibition of AXL signaling in anti-metastatic therapy

The present disclosure presents a general approach to engineering existing protein-protein interactions through domain addition and evolution. The disclosure teaches the creation of novel fusion proteins that include knottin peptides where a portion of the knottin peptide is replaced with a sequence that has been created for binding to a particular target. Such fusion proteins can also be bispecific or multi specific in that they can bind to and/or inhibit two or more receptors or receptor ligands. Knottins may be fused with an existing ligand (or receptor) as a general platform for increasing the affinity of a ligand-receptor interaction or for creating a multi specific protein. In addition, the fusion proteins may comprise a knottin peptide fused to another protein where the other protein facilitates proper expression and folding of the knottin.

The grill of the present disclosure provides multiple heating zones within a front-to-back direction of each cooking platen. Each cooking zone has a heating element associated therewith. The heating elements can be independently controlled, so that each of the heating zones can be operated at a different temperature if necessary. A controller can monitor and adjust the heat output of each element with a temperature probe that measures the temperature of the surface of the grill plate. One or more of the heating elements can be a gas burner. Electrical heating elements may also be used.

Cooking grill with multiple gas heating zones front to back for improved grill plate temperature management

A spinning amusement device is provided which may include a first arm coupled to an opposing second arm. A neck aperture may be disposed centrally between the first arm and the second arm. A first seat may be coupled to the first arm, and a second seat may be coupled to the second arm. Preferably, the device may be used by an adult user who may position their neck in the neck aperture, a first child user received in the first seat in a seated position, and a second child received in the second seat also in a seated position. The adult user may rotate the device, preferably by rotating their own body with the first arm and second arm, and the two children may therefore be spun or rotated while the majority of the centrifugal force of the children is borne by the device and by the children which are in a seated position.

Spinning amusement device

Compositions and methods are provided for alleviating endometriosis, kidney disease, inflammatory disease and/or transplant rejection in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.

Inhibition of AXL/GAS6 signaling in the treatment of liver fibrosis

Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization.

Polypeptides targeting vascular endothelial growth factor receptor-2 and &#x3b1;v&#x3b2;3 integrin

Polypeptides targeting vascular endothelial growth factor receptor-2 and alpha V beta 3 integrin

The modular grill of the present disclosure contains a plurality of removably connected sub-unit grills, each having their own associated control system. This allows for easy servicing and removal of each sub-unit. In addition, each sub-unit can be set to different cooking parameters if desired, thus allowing for the cooking of different products within the same grill.

Modular two-sided grill

Growing community of inventors

New Port Richey, FL, United States of America

Douglas Scott Jones