University of Pennsylvania

The Wistar Institute

Douglas S Williams

Eric L Meggers

Ronen Marmorstein

Howard Bregman

Peng Xie

Provided are novel organometallic compounds that inhibit PI3K lipid kinase and phospho-AKT in human melanoma cells, and also inhibit the migration of melanoma cells. The present invention is also directed to methods for inhibiting cancer cell proliferation, migration or both comprising contacting a cancer cell with a disclosed organometallic kinase inhibitor. Also disclosed are methods for treating a kinase-affected disease or condition comprising administering to a subject in need thereof a therapeutically effective amount of a disclosed organometallic kinase inhibitor.

Metal complex phosphatidyl-inositol-3-kinase inhibitors

The present inventive subject matter relates to novel metal complex glycogen synthase kinase 3 inhibitors, methods for making such compounds, and methods for using such compounds for treating diseases and disorders mediated by glycogen synthase kinase 3 activity. Compound II, below, represents an exemplary metal complex glycogen synthase kinase 3 inhibitor according to the present disclosure, wherein variable groups are defined as provided herein: 

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Philadelphia, PA, United States of America

Douglas S Williams