Howard Hughes Medical Institute

Other

Douglas S Kim

Loren Lee Looger

Karel Svoboda

Rex Kerr

Eric R Schreiter

Lo Chun-Hoi

Genetically encoded calcium indicator (GECI) polypeptides and the nucleic acid molecules encoding such polypeptides are provided. In addition, methods of using such nucleic acids and polypeptides in methods of screening for agonists or antagonists of G-protein coupled receptor (GPCR) or ion channels and methods of monitoring neural activity also are provided.

Genetically encoded calcium indicators and methods of use

Game apparatus comprising a plurality of multi-sided, game and base pieces having notches whereby the pieces may be interlocked, and said pieces having two faces with indicia or other markings on at least some of the faces whereby words and/or equations and/or other things can be formed along horizontal and/or vertical and/or diagonal axes by placing game pieces adjacent to each and/or game pieces and/or base pieces interlocked into each other. Methods for playing games with said apparatus in two and/or three dimensions is disclosed.

Word game with multi-sided pieces with notches for interlocking of the pieces at various angles

Protein indicators useful for calcium imaging, in particular, red genetically-encoded calcium indicators (GECIs) disclosed herein rival best-of-class green GECIs in terms of sensitivity for detecting neural activity, and can be monitored in vivo. The presently-disclosed subject matter further includes a method of monitoring cell activity comprising stimulating a cell comprising a red GECI polypeptide; and detecting fluorescence emitted by the cell.

Red genetically encoded calcium indicators and methods of use

Genetically encoded calcium indicators

Methods and systems are disclosed for storing cordage on a flexible carrier containing a plurality of holes, the cordage being quickly and easily removable from the flexible carrier when a temporary securement securing an end of the cordage is disengaged and an end is pulled. The flexible carrier can be a cordage storage article, a strap, a panel, a belt, a piece of clothing, a piece of a backpack, carry bag, tent, etc.

System and methods for cordage storage/deployment and articles

Two dancing dolls, termed 'keiki' dolls, which in Hawaiian means 'child' or 'children' include a battery-operated drive mechanism which causes one of the dolls to shake its hips to the left and right, while the other doll simultaneously moves its legs towards and away from each other, pivoted about its heels, thereby also causing the upper torso of the doll to move. A three-position switch controls the movement of the dolls between an off position, a dancing position with musical accompaniment, and a dancing position without musical accompaniment. The single drive mechanism, through a series of gears, drives both dolls.

Dancing keiki dolls

A dancing hula doll which alternatively moves its hips left and right to give it a lifelikeness that compares with a real hula dancer. The doll includes an upper portion, a lower portion, and a base portion. The upper portion resembles and head through waist of a human; the lower portion resembles the waist through hip portion of a human. The upper portion is pivotally connected to the lower portion by a hinge pin. An activator pin is connected to the inner surface of the lower portion. The base portion supports the upper portion and the lower portion by a support rod, one end of which is secured to the base portion and the other end of which is placed in a cavity within the head of the upper portion. The base portion includes a housing with a turning plate secured to its bottom portion, a stationary base with feet spaced below the turning plate, a switch, a battery, a motor, an I.C. Electronic Melody Circuit, a speaker, a drive gear, a cam, a lever arm, a pivot at the middle portion of the lever arm, and gearing which will transmit the motion of the motor to the cam and will cause the turning plate to rotate slowly. When the switch is turned on, the motor turns the cam that in turn activates the lever arm that in turn moves the activator pin that in turn alternately moves the hips of the doll left and right, while the doll slowly turns counterclockwise and a Hawaiian melody is heard.

Growing community of inventors

Chevy Chase, MD, United States of America

Douglas S Kim