Albert Einstein College of Medicine

Victoria Link Limited

The Director General of the Ministry of Agriculture and Fisheries

Douglas Ronald Crump

Vern L Schramm

Peter Charles Tyler

Shivali Ashwin Gulab

Quan Du

Anthony David Woolhouse

Kenneth Pattrick McNatty

Karl Jürgen Shaffer

Ashna Ashneen Khan

Anton F Erasmuson

Farah Lamiable-Oulaidi

Provided herein are inhibitors of DNA methyltransferase 1 (an enzyme responsible for the maintenance of DNA CpG methylation marks in human cells) and their use for inhibiting DNA methyltransferase 1. The invention relates to compounds, pharmaceutical compositions, and methods for inhibiting DNA methyltransferase 1. The inhibitors are compounds of the general formula: 

Inhibitors of DNMT1 as anticancer therapeutic agents

A product and method for increasing fertility in sheep. By 'increasing felity' is meant increasing the potential of a flock of sheep to multiply by increasing ovulation in ewes. The product is an immunogenic conjugate of 4-androstene-3, 17-dione and a soluble milk protein (SMP): 6-hydroxyandrost-4-ene-3, 17-dione 6-hemisuccinyl: SMP. The method comprises immunizing the ewes in a flock of sheep against 4-androstene-3, 17-dione by administering 6-hydroxyandrost-4-ene-3, 17-dione 6-hemisuccinyl SMP at the rate of 3 to 5 mg per ewe. In previously untreated ewes, two administrations are required at between 8 to 9 and 4 to 5 weeks before the planned commencement of mating. Subsequent administrations are annually and are recommended at 5 weeks before the commencement of mating.

Method and product for increasing fertility in sheep using milk protein

Growing community of inventors

Wellington, New Zealand

Douglas Ronald Crump