The Upjohn Co.

Other

Douglas R Morton

Gordon L Bundy

Roy A Johnson

Gilbert A Youngdale

Donald P Wallach, Deceased

By Vera Wallach, Legal Representative

Wallach, Legal Representative, By Vera M

Vera M Wallach, Legal Representative

Provided are cyclic hydrocarbons of Formula I ##STR1## with an aminoalkyl sidechain that are useful for treating phospholipase A2 mediated conditions, diabetes, and obesity.

Cyclic hydrocarbons with an aminoalkyl sidechain

Steroid compounds

Provided are cyclic hydrocarbons of Formula I ##STR1## with an aminoalkyl sidechain.

Prostacyclin (PGI.sub.2) analogs having a 6a-carba feature, for example a compound of the formula ##STR1## said analogs having pharmacological activity. Processes for preparing them and the appropriate intermediates are disclosed.

Prostacyclin analogs

Prostaglandin analogs with the following cyclopentane ring structure: ##STR1## are disclosed along with intermediates useful in their preparation and processes for their preparation. These analogs are useful for the same pharmacological purposes as the prostaglandins, particularly and especially as blood platelet aggregation inhibitors.

.omega.-Aryl-PGD compounds

The present invention provides novel analogs of the thromboxanes. These thromboxane analogs are useful for a variety of pharmacologically useful purposes, most particularly as antithrombotic agents.

9,11-Dideoxy-10-oxa-TXB intermediates

The present invention relates to novel compositions of matter and particularly provides 9,11-dideoxy-10-oxa-TXB intermediates for preparing corresponding thromboxane analogs. These thromboxane analogs are useful for a variety of pharmacologically useful purposes, most particularly as anti-thrombotic agents.

The present specification discloses novel 9,11-dideoxy- or 9,11,15-trideoxy-10-oxa-thromboxane B compounds, their novel method of preparation and the pharmaceutical compositions and use thereof as antihrombotic, antiinflammatory, and antiasthma agents.

9,11-Dideoxy-10-oxa-TXB compounds

The present invention relates to novel 2-decarboxy-2-aminomethyl-6a-carba-PGI.sub.2 compounds, which are useful for inducing a variety of prostacyclin-like pharmacological effects. Accordingly, these compounds are useful pharmacological agents for the same purposes for which prostacyclin is employed.

2-Decarboxy-2-aminomethyl-6a-carba-PGI.sub.2 compounds

The present invention relates to two novel compounds, the pharmacologically acceptable salts thereof and their preparation and use as pharmacological agents. These novel compounds are

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Portage, MI, United States of America

Douglas R Morton