Cytovia, Inc.

Other

University of California

La Jolla Institute for Allergy and Immunology

Douglas R Green

Eckard Weber

Gordon B Mills

Sui Xiong Cai

Yan Wang

Gary S Firestein

Nathan J Zvaifler

Shailaja Kasibhatla

Ben Y Tseng

Thomas G Cotter

Lufeng Guan

A method for identifying therapeutically effective immunosuppressive agents by screening such agents for those which induce apoptosis in activated T cells is disclosed. T cells were isolated then activated and treating with various test compounds. A caspase substrate is added to detect caspase activation and apoptosis in the cells. Compounds which stimulate caspase activation and apoptosis are also tested against resting T cells to determine those agents which are more effective in activated T cells compared to resting T cells. Compounds with this selectivity are effective in treating immunopathological disorders such as arthritis, graft rejection, graft versus host disease, inflammatory bowel syndrome and the like.

Method of identifying immunosuppressive agents

The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.

Therapy for cellular accumulation in chronic inflammatory diseases

Caspase inhibitors and the use thereof

The use of caspase inhibitors for treating, ameliorating, and preventing non-cancer cell death during chemotherapy and radiation therapy and for treating and ameliorating the side effects of chemotherapy and radiation therapy of cancer is disclosed.

Caspase inhibitors for the treatment and prevention of chemotherapy and radiation therapy induced cell death

Substituted alpha-hydroxy acid caspase inhibitors and the use thereof

Methods for treating arthritis by administering an apoptosis regulator

A method is disclosed for enhancement of the efficacy of therapeutic treatment for inducing cell death in a cell having an anti-apoptotic gene by the enhancement of apoptosis. An antisense oligonucleotide is disclosed which hybridizes with the nucleic acid sequence of the anti-apoptotic gene. The oligonucleotide is administered to the cell in an amount sufficient to inhibit expression of the gene, thus rendering the cell susceptible to induction of apoptosis, and consequently achieving higher efficacy of therapeutic treatment.

Enhancement of adoptosis using antisense oligonucleotides

Articles of furniture are formed employing at least three members joined together by mortises and tenons of which one is a first member, when an additional member or members are needed, one such is the mirror image of the first member. In all disclosed embodiments, each first member or members has a first mortise which extends from one end margin at least part way towards the opposite end portion and a second mortise extending from the fist side margin towards the opposite side margin, intersecting the first mortise and extending beyond it. Another member has a tenon, for each first member extending part way along each side margin and is dimensioned to enable it to be entered in a first mortise and slid in one direction towards the opposite end portion of the first member into a position in which the second mortise thereof is unblocked and in the opposite direction into a position blocking the second mortise. An additional member has a tenon for each second mortise and can be slid therein with the another member in its first position and held therein when that member is in its second position, a mortise and tenon that connects said another and additional members. At least one of the mortise and tenon connections is a self-locking connection.

Furniture constructions

Growing community of inventors

San Diego, CA, United States of America

Douglas R Green