Louisiana State University and Agricultural & Mechanical College

Abbott Laboratories Corporation

Battelle Pulmonary Therapeutics, Inc.

Theravasc Inc.

Douglas R Flanagan

Panayiotis P Constantinides

Christopher Kevil

Anthony J Giordano

Anthony Rocco Imondi

Michael E Placke

Michael J Brooker

Praful K Shah

John E Frye

Carmela H Luangdilok

Matthew M Widman

Luk-Chiu Li

Maureen D Donovan

Anthony Giordano

The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.

Pharmaceutical formulations of nitrite and uses thereof

An oil-in-water buprenorphine formulation including buprenorphine and a surfactant that emulsifies the buprenorphine in oil, wherein the drug release is controlled by varying the oil concentration and/or pH. A buprenorphine aqueous suspension formulation including a free base buprenorphine and a suspension stabilizer. A buprenorphine oil formulation including a buprenorphine salt suspended in a pharmaceutically acceptable oil. Methods of providing sustained release of buprenorphine over a period of time.

Sustained release parenteral formulations of buprenorphine

A formulation, method, and apparatus for treating neoplasms such as cancer by administering a pharmaceutically effective amount of highly toxic composition by inhalation, wherein the composition is a non-encapsulated antineoplastic drug.

Formulation and method for treating neoplasms by inhalation

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Iowa City, IA, United States of America

Douglas R Flanagan