Noramco Gmbh

Douglas Phillip Cox

Dominique Roberge

Ulrich Weigl

Aeri Park

Jasper Kaiser

Christian Oliver Kappe

Hemen Ibrahim

Govert Arie Verspui

Bernhard Gutmann

Abram Calderon

Patrick Thomas Cyr

Petteri Elsner

Pietertje Elisabeth Goudriaan

The present disclosure relates to N-demethylation of a compound containing a tertiary N-methylamine, including for example a morphinan alkaloid, in a continuous flow system. In particular, the present disclosure relates to N-demethylation of oxymorphone-3,14-diacetate or 14-hydroxymorphinone-3,14-diacetate using highly active catalytic palladium (0) in a continuous flow system under elevated temperature and pressure condition. The methodology can be utilized towards the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation.

N-demethylation of morphinan alkaloids

The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product is advantageously enantiomerically or diastereomerically enriched in the desired stereoisomer.

Process for the preparation of lisdexamfetamine and related derivatives

Oxycodone.HCl polymorph forms are disclosed which are useful as analgesic agents either in combination with or as replacements for oxycodone.

Oxycodone polymorphs

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Eagleville, PA, United States of America

Douglas Phillip Cox