Kci Licensing, Inc.

Southwest Research Institute

University of Texas System

Douglas Philip Hanson

James Courage

Stephen Thomas Wellinghoff

Christopher A Carroll

Amy K McNulty

Todd Fruchterman

Diwi L Allen

Anthony Rycerz

Stanton F McHardy

Waldemar Gorski

Travis Menard

Andrew Fleischman

Certain embodiments are directed hydrophilic redox substrates for leukocyte esterase (LE). In certain aspects a hydrophilic redox leukocyte esterase substrate or a small molecule enzyme substrate for use in methods and/or devices to electrochemically detect and/or measure LE activity in a sample.

Redox substrates for leukocyte esterase

The present disclosure provides amine-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include a covalently attached molecule comprising free amine groups. Such amine groups can be used, for instance, to conjugate biologically active polypeptides and/or linkers. Methods for using modified polymers are also provided.

Amine-functionalized polymeric compositions for medical devices

Aptamer-modified polymers and materials thereof, used for binding factors in a wound bed. The aptamer-modified materials can be polypeptides conjugated to polymer foam materials and used, for example, as dressings, wound inserts, or pads.

Aptamer-modified polymeric materials for the binding of factors in a wound environment

Methods and compositions for the enzymatic debridement of wounds are provided. Methods for preparing enzymatic debridement compositions are also provided. In one embodiment, an enzymatic debridement composition prepared by dissolving crude bromelain in a composition comprising a weak acid, and filtering and/or dialyzing the dissolved crude bromelain to obtain the enzymatic debridement composition is provided.

Composition for enzymatic debridement

The present disclosure provides sulfhydryl-modified polymer foams, which may be used for wound dressing materials. For example, the modified materials can include free sulfhydryl group, which can serve as a linker to attach biologically active molecules. For example, sulfhydryl groups can be used to conjugate biologically active polypeptides and/or metals to foam polymers. Methods for using sulfhydryl-modified polymers, such as for wound dressings, are also provided.

Sulfhydryl-functionalized polymeric compositions for medical devices

The present invention provides aptamer-modified polymers and materials thereof, which may be used for the binding of factors in a wound bed. For example, the aptamer-modified materials can be polypeptides conjugated to polymer foam materials. Such materials may be used, for example, for dressings, wound inserts, or pads.

Novel platform mesogens, intermediates, and polymerizable mesogens made therefrom.

Mesogens

A method for making platform molecules comprising: reacting 4-alkoxy benzoyl chloride with R-hydroquinone under first conditions effective to produce bis 1,4[4-alkoxy-benzoyloxy]-R-phenylene comprising bis terminal alkoxy groups wherein Ris a bulky organic group; and, subjecting the bis 1,4[4-alkoxy-benzoyloxy]-R-phenylene to second conditions effective to selectively cleave the bis terminal alkoxy groups to produce a solution comprising complexes comprising diphenolic platform molecules comprising bis terminal hydroxyl groups, the second conditions also being effective to precipitate the complexes out of the solution.

Selective ether cleavage synthesis of liquid crystals

A method for producing a blend comprising randomly substituted mesogens comprising: providing one or more platform molecules have the following general structure: wherein at least one member selected from the group consisting of X and Y comprises one or more spacer groups; Ris a bulky organic group whereby, when both X and Y are reacted with polymerizable groups to produce polymerizable mesogens, Rprovides sufficient steric hindrance to achieve a nematic state at room temperature while suppressing crystallinity of the polymerizable mesogens at room temperature; and, Rand Rare selected from groups less bulky than R; and independently substituting at least one member selected from the group consisting of X and Y with a polymerizable group, thereby producing a blend of randomly substituted mesogens.

Methods and blends for controlling rheology and transition temperature of liquid crystals

New, efficient methods for making novel platform molecules and polymerizable mesogens are provided, as well as the novel mesogens and methods of using same.

Mesogens and methods for their synthesis and use

A resin blend and method of producing the resin blend, the resin blend comprising one or more first liquid crystal monomer at a ratio to one or more secondary monomer, said secondary monomer and said ratio being adapted to maintain said resin blend in a nematic liquid crystalline state after addition of an inorganic filler at a temperature of 20&#xb0; C. for about 30 minutes or more, the resin blend having a polymerization shrinkage of 3 vol. % or less.

Resin blends and methods for making same

A method for producing platform molecules comprising: forming a mixture comprising first and second phenylene rings comprising halogenated carboxylic groups, and a third phenylene ring comprising a desired substituent and a first functionality at a para-position to a second funcitonality; and exposing the mixture to conditions effective to react the first halogenated carboxylic group with the first functionality to produce a first ester bond, and the second halogenated carboxylic group with the second functionality to produce a second ester bond; producing platform molecules comprising terminal groups comprising the first functional group at a position para to first ester bond and the second functional group at a position para to the second ester bond.

Growing community of inventors

San Antonio, TX, United States of America

Douglas Philip Hanson