Roche Diagnostics Gmbh

Roche Diagnostics Operations, Inc.

F. Hoffmann-la Roche Ag

Douglas Paul Walling

Raghbir Singh Bhullar

Brian S Hill

Henning Groll

James L Pauley

John T Austera

Eric R Diebold

Nigel A Surridge

Timothy L Ranney

Timothy I Ranney

The present invention relates to a biosensor. The biosensor includes a support substrate, an electrically conductive coating positioned on the support substrate, the coating being formed to define electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and a cover cooperating with the support substrate to define a channel. At least a portion of the electrodes are positioned in the channel.

Biosensor

The present invention relates to a method of forming a biosensor. The method includes providing a substrate coated with a electrically conductive material, ablating the electrically conductive material to form electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and applying a reagent to at least one of the electrodes.

Method of making a biosensor

A method of making a biosensor is provided. The method includes providing an electrically conductive material on a base and partially removing the conductive material using laser ablation from the base so that less than 90% of the conductive material remains on the base and at least one electrode pattern is formed from the conductive material. The at least one electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 &#x3bc;m along the length of the edge.

A method of making a biosensor is provided. The biosensor includes an electrically conductive material on a base and electrode patterns formed on the base, the patterns having different feature sizes. The conductive material is partially removed from the base using broad field laser ablation so that less than 90% of the conductive material remains on the base and that the electrode pattern has an edge extending between two points. A standard deviation of the edge from a line extending between two points is less than about 6 &#x3bc;m.

A biosensor is provided that comprises a substrate, a sample site positioned on the substrate, a cover coupled to the substrate, and biocide positioned between the substrate and the cover. The biosensor may also include desiccant. The cover is operative to selectively block access to the sample site. The cover includes a fixed end coupled to the substrate, an opposite free end, and a middle portion extending across the sample site. The middle portion is releasably and recloseably adhered to the substrate.

Recloseable biosensor

A method of forming a biosensor is provided. The method includes providing a substrate and a cover including first and second surfaces, positioning a reagent on the substrate, carving a channel by laser ablation in the first surface, and coupling the first surface of the cover to the second surface. The channel includes a first portion having a first height and a second portion having a second height that is less than the first height.

A biosensor is provided that comprises a substrate, a reagent positioned on the substrate, and a cover including a top side and a generally flat bottom side. The bottom side is coupled to the substrate to define a sealed portion and an unsealed portion. The unsealed portion cooperates with the substrate to define a channel extending across the reagent.

The present invention relates to a biosensor. The biosensor includes a support substate, an electrically conductive coating positioned on the support substrate, the coating being formed to define electrodes and a code pattern, wherein there is sufficient contrast between the conductive coating and the substrate such that the code pattern is discernible, and a cover cooperating with the support substrate to define a channel. At least a portion of the electrodes are positioned in the channel.

Biosensor with code pattern

According to an aspect of the invention, an electrochemical cell for analysis of a sample is provided, comprising a dual electrode having a dielectric strip with electrical conductors on opposite sides. According to a preferred embodiment, the electrochemical cell comprises a base, and a first reagent the proximate the dual electrode. According to a further preferred embodiment, a second reagent is provided proximate the dual electrode. A cover may also be provided comprising a sample aperture. According to a particularly preferred embodiment, the first and second reagents are superposed, and the dual electrode is between the first and second reagents. The dual electrode separates the two and preserves chemical stability until a sample is applied.

Cell for electrochemical anaylsis of a sample

A biosensor is provided that comprises a substrate, a reagent positioned on the substrate, and a cover including a first surface coupled to the substrate and a second surface. The first surface is carved so that it includes a flow channel therein. The flow channel extends over at least a portion of the reagent. In addition, the cover includes secondary channels extending on either side of the channel.

A recloseable biosensor is provided that comprises a substrate, a sample site positioned on the substrate, and an openable and recloseable cover coupled to the substrate. The cover is operative to selectively block access to the sample site. The cover includes a fixed end coupled to the substrate, an opposite free end, and a middle portion extending across the sample site. The middle portion is releasably and recloseably adhered to the substrate.

A biosensor is provided in accordance with this invention. The biosensor includes a bottom section with an edge and a flange extending from the edge, a top section supported on the bottom section and having an edge and flange extending from the edge in alignment with the flange of the bottom section. The flanges of the top and bottom sections cooperate to form a capillary channel, and first and second electrodes. Additionally, the first electrode is positioned on the flange of the bottom section in the capillary channel and the second electrode is positioned on the flange of the top section in the capillary channel.

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Indianapolis, IN, United States of America

Douglas Paul Walling