Xerox Corporation

Palo Alto Research Center Inc.

The Scripps Research Institute

Sri International

Douglas N Curry

Robert P Loce

David Kirtland Fork

Robert Thomas Krivacic

Patrick Yasuo Maeda

Timothy D Stowe

Richard H Bruce

Donald James Curry

Huangpin Ben Hsieh

David L Hecht

Alan G Bell

Mark Jeffrey Stefik

Richard A Lerner

Daniel H Greene

Robert L Thornton

Leon C Williams

Fritz F Ebner

David Goldberg

Ana Claudia Arias

Todd A Cass

Yeqing Zhang

Michael Branciforte

Thomas A Berson

Matthew K Franklin

Teresa F Lunt

Thomas M Breuel

Robert P St John

Sofia Filshtinsky

Nicole H Lazarus

R Drew Dean

Ben H Hsieh

Nicole Hanson Lazarus

Substantially one-dimensional scan line images at 1200 dpi or greater are generated in response to predetermined scan line image data. A substantially uniform two-dimensional homogenous light field is modulated using a spatial light modulator in accordance with the predetermined scan line image data such that the modulated light forms a two-dimensional modulated light field. The modulated light field is then anamorphically imaged and concentrated to form the substantially one-dimensional scan line image. The spatial light modulator includes light modulating elements arranged in a two-dimensional array. The light modulating elements are disposed such that each modulating element receives an associated homogenous light portion, and is individually adjustable between an 'on' modulated state and an 'off' modulated state, whereby in the &#x201c;on&#x201d; modulated state each modulating element directs its received light portion onto a corresponding region of the anamorphic optical system, and in the &#x201c;off&#x201d; state blocks or diverts the light portion.

Single-pass imaging method using spatial light modulator and anamorphic projection optics

An imaging (e.g., lithographic) apparatus for generating an elongated concentrated scan image on an imaging surface of a scan structure (e.g., a drum cylinder) that moves in a process (cross-scan) direction. The apparatus includes a spatial light modulator having a two-dimensional array of light modulating elements for modulating a two-dimensional light field in response to predetermined scan image data, and an anamorphic optical system is used to anamorphically image and concentrate the modulated light onto an elongated imaging region defined on the imaging surface. To avoid smearing, movement of the imaging surface is synchronized by an image position controller with the modulated states of the light modulating elements such that image features of the scan image are scrolled (moved in the cross-scan direction) at the same rate as the cross-scan movement of the imaging surface, whereby the features remain coincident with the same portion of the imaging surface.

Single-pass imaging apparatus with image data scrolling for improved resolution contrast and exposure extent

An imaging method for generating a substantially one-dimensional scan line image using multiple spatial light modulators, to modulate a homogenous light field, and then anamorphically imaging and concentrating the modulated light to form the scan line image. The spatial light modulators include light modulating elements that are arranged in two-dimensional array and are individually adjustable to either pass/reflect received homogenous light portions to the anamorphic optical systems, or to block/redirect the homogenous light portions, thereby generating two-dimensional modulated light fields. Anamorphic optical systems are used to image and focus received modulated light field onto an associated substantially one-dimensional scan line portion on the scan structure. An image stitching controller modifies the image data sent to each spatial light modulator such that selected light modulating elements are enabled or disabled, thereby electronically stitching the scan line portions to form a seamlessly stitched scan line image.

Variable length imaging method using electronically registered and stitched single-pass imaging

A method for generating an elongated concentrated scan image on an imaging surface of a scan structure (e.g., a drum cylinder) in an imaging (e.g., xerographic or lithographic) apparatus, wherein the imaging surface is caused to move in a cross-scan (process) direction. A spatial light modulator having a two-dimensional array of light modulating elements is used to modulate a two-dimensional light field in response to predetermined scan image data, and then the modulated light is anamorphically imaged and concentrated onto an elongated imaging region defined on the imaging surface. To avoid smearing, movement of the imaging surface is synchronized with the modulated states of the light modulating elements such that image features of the scan image are scrolled (moved in the cross-scan direction) at the same rate as the cross-scan movement of the imaging surface, whereby the features remain coincident with the same portion of the imaging surface.

Single-pass imaging method with image data scrolling for improved resolution contrast and exposure extent

An imaging apparatus including multiple spatial light modulators, each including light modulating elements arranged in two-dimensional array disposed in a homogenous light field, multiple anamorphic optical systems, each disposed downstream from an associated spatial light modulator, a scan structure, and an image stitching controller. The light modulating elements of each spatial light modulator are individually adjustable to either pass received homogenous light portions to the anamorphic optical systems, or to block/redirect the homogenous light portions, thereby generating a two-dimensional modulated light field. Each anamorphic optical system images and focuses received modulated light field onto an associated substantially one-dimensional scan line portion on the scan structure. The image stitching controller modifies the image data sent to each spatial light modulator such that selected light modulating elements are enabled or disabled, thereby electronically stitching the scan line portions to form a seamlessly stitched scan line image.

Variable length imaging apparatus using electronically registered and stitched single-pass imaging systems

A single-pass imaging system for a printing apparatus capable of 1200 dpi or greater that includes a homogenous light generator for generating homogenous light from high energy IR lasers, a spatial light modulator including light modulating elements arranged in a two-dimensional array, and an anamorphic optical system. The light modulating elements are disposed such that each modulating element receives an associated homogenous light portion, and is individually adjustable between an 'on' modulated state and an 'off' modulated state, whereby in the &#x201c;on&#x201d; modulated state each modulating element modulates its received homogenous light portion such that an associated modulated light portion is directed onto a corresponding region of the anamorphic optical system. In the second modulated state, the associated homogenous light portion is prevented (e.g., blocked) from passing to the anamorphic optical system. The anamorphic optical system then anamorphically concentrates the modulated light portions to form a scan line image.

Single-pass imaging system using spatial light modulator anamorphic projection optics

A method is provided for preparing a sample containing potential cells of interest and of using a laser of a laser based system for novel excitation and emission collection, and data usage including use of obtained data for direct and ratio based measurements. The prepared sample is configured to emit signals having spectral characteristics sufficient to permit filtering to differentiate and eliminate most false positives from true positives among acquired imaging events, in an imaging system employing a laser spot having a range of diameters from 1 to 20 &#x3bc;m or greater and which excites the fluorescence in a conventional or novel manner. These filtered events may be subsequently imaged and confirmed with another higher resolution device such as a fluorescent microscope in a short amount of time.

Immunocytostaining methods for enhanced dye ratio discrimination in rare event detection

A system and method permits for the separation of auto-fluorescence from a signal by applying a single probe to a sample, exciting the sample with a single wavelength light source, thereby emitting a light a distance from the light source. The emitted light is split, and the split light is collected into two or more distinct channels. A first channel of the distinct channels is positioned closer to the light source than a second distinct channel of the distinct channels, and the second channel is closer to the emission frequency of the single probe than is the first channel. The light collected in the first channel and the light collected in the second channel are investigated, and an output signal is generated based upon the investigation.

System and method for removing auto-fluorescence through the use of multiple detection channels

Xerox Reference No. D/A0639A system and method for improving xerographic halftoning by magnifying a threshold array, interpolating the in-between values, enabling multiple thresholds to be accessed simultaneously and presented to multiple comparators, to cause multi-bit output. A threshold array is sampled at distinct locations separated by the sparse sampling distance to allow warping of the threshold array dots by adjusting the sampling distance in small, fractional portions (deltas) of the magnified distance. By adding more thresholds, amplitude or intensity modulation is used to move dot edges in a process direction for further flexibility in printing irrational or warpable screens.

Multi-bit output sampled threshold array halftoner

The amount of moir&#xe9; in halftone printed images is reduced using unique moir&#xe9; intensity functions and moir&#xe9; vectors in a halftoner. In various embodiments, moir&#xe9; phase angle zones are determined over the full field of an image and high addressability units in the full-field moir&#xe9; phase angle zones of the image are adjusted, including in an iterative manner, until they significantly reduce the moir&#xe9;. A useful relationship between halftoner memory locations and moir&#xe9; phase angle zones in a full field image is determined. The moir&#xe9; that occurs in a halftone image is quantified and moir&#xe9; compensation values obtained are then used to generate an inverse moire amount which is used to compensate for the moir&#xe9;.

Computational moir&#xe9; compensation

Provided is a method for obtaining a position of an object. A slide which carries at least one object and has reticle marks arranged at positions which form substantially a right angle, is positioned in a slide holder of a first imaging system. A first coordinate space of the imaging system is defined, and coordinates of the reticle marks in the first coordinate space are designated. A second coordinate space of a second imaging system is defined, and the coordinates of the reticle marks in the second coordinate space is designated. Using the designated coordinates of the reticle marks of the first coordinate space, the coordinate conversion parameters are computed. Thereafter, coordinates of at least one object in the first coordinate space are designated, and the first coordinate space coordinates of the object are converted into unique coordinates in a second coordinate space, using the coordinate conversion parameters.

Method of converting rare cell scanner image coordinates to microscope coordinates using reticle marks on a sample media

An apparatus images a surface. An imager stage linearly translates the surface in a first direction. A light path has a first end defining an input aperture perpendicular to the first direction and parallel to the surface, and a second end defining an output aperture. A plurality of radiation beams linearly scan and interact in time-multiplexed alternating turns with the surface below the input aperture to produce a time-multiplexed light signal that is collected by the input aperture and transmitted by the light path to the output aperture. A photodetector arrangement detects the light signal at the output aperture. A processor processes the detected time-multiplexed light.

Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems

An apparatus images a surface. An imager stage has a planar surface for supporting a sample. A fiber optic bundle has a first end of parallel first fiber ends that are arranged to define an input aperture for viewing the sample on the imager stage. A distal bundle end is arranged to define an output aperture disposed away from the imager stage. A scanning radiation source scans a radiation beam along a path that is perpendicular to the sample on the imager stage. The input aperture of the fiber optic bundle receives a light signal that is produced by the radiation source scan of the imager stage sample. The light signal is transmitted to the bundle output aperture. A photodetector detects the light signal at the distal bundle end, and a processor processes the detected light.

Method of scanning and light collection for a rare cell detector

In accordance with one aspect of the present application, an imager and method for detecting and locating rare cells in a sample is disclosed. An imager stage supports the sample. A fiber optic bundle has a proximate bundle end of first fiber ends arranged to define an input aperture viewing the sample on the translation stage. The fiber optic bundle further has a distal bundle end of second fiber ends arranged to define an output aperture shaped differently from the input aperture and disposed away from the imager stage. A scanning radiation source is arranged in fixed relative position to the input aperture. The scanning radiation source scans a radiation beam on the sample within a viewing area of the input aperture. The radiation beam interacts with the sample to produce a light signal that is reflected, scattered, transmitted, re-emitted, or otherwise collected and received by the input aperture and transmitted via the fiber optic bundle to the output aperture. The scanning radiation source rasters the radiation beam over a selected area of the sample. A photodetector is arranged to detect the light signal at the distal bundle end, and a processor processes the detected light signals.

Apparatus and method for detecting and locating rare cells

A compression and decompression system and process for optimally compressing and decompressing multibit per pixel image regions based on the type of data contained in the image region, e.g., whether the image region contains continuous tone data, including data to be halftoned, or non-continuous tone data, including antialiased text and lineart data. Segmented bytemap data blocks are processed to provide both low spatial resolution continuous tone data and high spatial resolution non-continuous tone data. However, the high spatial resolution non-continuous tone data is generated by quantizing and packing the high resolution bytes across an edge and discarding the high resolution bytes along the edge, i.e., the multibit data is discarded only in directions parallel to the edges of marks to be rendered in the image data. Additional information indicating the directions of the edges in the image data are stored to aid in decompression. Subsequently, during decompression, the non-continuous tone data is decompressed into a high spatial resolution bytemap by unpacking the high resolution across the edges and inferring the high resolution along the edges. The low spatial resolution continuous tone data are processed to provide a low spatial resolution continuous tone data bytemap. As a result of this compression and decompression method, the amount of memory necessary to store the non-continuous tone data is reduced to a quarter of the memory necessary to store a conventional high spatial resolution bytemap.

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Menlo Park, CA, United States of America

Douglas N Curry