Oculeve, Inc.

Leland Stanford Junior University

Boston Scientific Neuromodulation Corporation

Oyster Point Pharma, Inc.

Tangible Science, LLC

Case Western Reserve University

Ocular Dynamics, LLC

Presidio Medical, Inc.

Douglas Michael Ackermann

James Donald Loudin

Garrett Cale Smith

Brandon McNary Felkins

Victor Wayne McCray

Daniel V Palanker

John L Wardle

Manfred Franke

Daniel N Hamilton

Janusz Kuzma

Evan Scott Luxon

Kenneth Jason Mandell

Karen L Havenstrite

Paul Cook

Andrew A McGibbon

John W Lai

Jarren Armond Baldwin

Christopher William Stivers

Natalie Catherine Vanns

Anne Margaret Pianca

Dennis Zottola

Samuel Tahmasian

Joonho Hyun

Daniel Aghassian

Kevin L Kilgore

Niloy Bhadra

Kenneth S Wu

Narendra Bhadra

Anand Doraiswamy

Kenneth Wu

Scott Franklin Wetenkamp

Aaron Hardinger

Paul Taehyun Yun

Daniel Ahassian

Victor W Mccray

Andrew A Mcgibbon

Brandon Mcnary Felkins

Victor Wayne Mccray

Dennis Ralph Zottola

Joonhu Hyun

Paul A Cook

Embodiments of the technology relate to a contact lens having a core that is covalently coated by a hydrogel layer, and to methods of making such a lens. In one aspect, embodiments provide for a coated contact lens comprising a lens core comprising an outer surface; and a hydrogel layer covalently attached to at least a portion of the outer surface, the hydrogel layer adapted to contact an ophthalmic surface, wherein the hydrogel layer comprises a hydrophilic polymer population having a first PEG species and a second PEG species, the first PEG species being at least partially cross-linked to the second PEG species.

Contact lens with a hydrophilic layer

A stimulation system stimulates anatomical targets in a patient for treatment of dry eye. The system may include a controller and a microstimulator. The controller may be implemented externally to or internally within the microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a controller signal and apply the signal via one or more electrodes to an anatomical target. The microstimulator may not have any intelligence or logic to shape or modify a signal. The microstimulator may be a passive device configured to generate a pulse based on a signal received from the controller. The microstimulator may shape or modify a signal. Waveforms having different frequency, amplitude and period characteristics may stimulate different anatomical targets in a patient.

Systems and methods for treatment of dry eye

Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue.

Nasal stimulation for rhinitis, nasal congestion, and ocular allergies

Nasal stimulator body

Described here are devices and methods for increasing ocular mucin and other tear protein release using intranasally delivered electrical stimulation. Generally, the devices may deliver electrical stimulation to the nasal mucosa. Intranasal stimulation may trigger degranulation of conjunctival goblet cells, which in turn releases secretory mucins into the tear fluid. The intranasal stimulation may also trigger release of lysozyme, lactoferrin, and other tear proteins into the aqueous layer of the tear film. The methods may further comprise obtaining feedback relating to the efficacy of the delivered electrical stimulation by measuring impedance or an electromyogram (EMG) signal.

Intranasal stimulation for enhanced release of ocular mucins and other tear proteins

Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

Nasal stimulation devices and methods for treating dry eye

Described here are systems, devices, and methods for implanting a nasal stimulator into nasal tissue and electrically stimulating nasal tissue. In some variations, a nasal microstimulator implantation system may comprise an implantation tool and an implantable microstimulator. An implantation tool may comprise a shaft and features to releasably attach a microstimulator. A microstimulator may comprise a passive stimulation circuit and one or more electrodes. In other variations, a nasal implantation system may additionally comprise one or more additional devices, such as a controller, an electrical probe, and/or a dissection tool.

Implantable nasal stimulator systems and methods

Nasal stimulator probe

Nasal stimulation devices and methods

Nasal stimulator device

Growing community of inventors

San Francisco, CA, United States of America

Douglas Michael Ackermann