Oculon Corporation

Massachusetts Institute of Technology

Other

Douglas L Hayden

George B Benedek

George M Thurston

Victor G Taratuta

Joyce A Peetermans

Mark S Bowen

A new model autocorrelation function is provided to which autocorrelation data is fit. The model function is empirically derived based on previously collected autocorrelation data and is indicative of the degree of cataractogenesis. The model autocorrelation function contains five parameters to characterize first and second portions of a fitted curve. In one embodiment, the model autocorrelation function has a single exponential and a single second order polynomial component to represent the first and second portions of the fitted curve, respectively. In an alternative form, the square root of the autocorrelation function is used as the model with the square root form being linear in four of five terms. The linearity in four of five terms permits the fitting of the data points to the model function using simple linear regression analysis. Other forms of mathematical models, such as a straight line first portion and a parabolic second portion may use five parameters to model the autocorrelation data.

System and method for detecting cataractogenesis using quasi-elastic

An apparatus is disclosed for using quasielastic light scattering to determine the degree of cataractogenesis of a lens in vivo. By collecting and analyzing light scattered from the lens, it is possible, using the temporal autocorrelation function, to produce a signature of cataractogenesis, accounting for scattering due to immobile scatterers. The components of the cataractogenesis can also be detected by comparing the values of the components of the signature of cataractogenesis to frequency distribution of the components taken from populations or by detecting changes in the values of the components of the signature of cataractogenesis as a function of time.

Apparatus for detecting cataractogenesis

A method and apparatus for detecting cataractogenesis is disclosed. Quasielastic light scattering data are collected from the lens of an individual to be tested for cataractogenesis. The data are collected from the lens and are processed by an autocorrelator. The data from the autocorrelator are then fit to an autocorrelation function having a component which has a second derivative less than or equal to zero. This autocorrelation function has been found to change predictably with the individual's age and, accordingly, is useful in detecting and determining the degree of cataractogenesis in the individual.

Method and apparatus for detecting cataractogenesis

A method and an apparatus are disclosed for using quasielastic light scattering to determine the degree of cataractogenesis of a lens in vivo. By collecting and analyzing light scattered from the lens, it is possible, using the temporal autocorrelation function, to produce a signature of cataractogenesis, accounting for scattering due to substantially immobile scatterers. The component of the temporal autocorrelation function representing the effect of the substantially immobile scatterers is expressed as a function of the measurement delay time. The components of the cataractogenesis can also be detected by comparing the values of the components of the signature of cataractogenesis to frequency distribution of the components taken from populations or by detecting changes in the values of the components of the signature of cataractogenesis as a function of time.

A method and apparatus for detecting cataractogenesis is disclosed. Quasielastic light scattering data are collected from the lens of an individual to be tested for cataractogenesis. The data are collected from specific and reproducible sites within the lens by means of measurements made using a reticle in the apparatus and processed by an autocorrelator. The data from the autocorrelator are then fit to a double exponential form of autocorrelation function and the resulting functional form is transformed to produce at least one dimensionless parameter F.sub.mos. This parameter has been found to change predictably with the individual's age and, accordingly, is useful in detecting and determining the degree of cataractogenesis in the individual.

A method and an apparatus are disclosed for using quasielastic light scattering to determine the degree of cataractogenesis of a lens in vivo. By collecting and analyzing light scattered from the lens, it is possible, using the temporal autocorrelation function, to produce a signature of cataractogenesis, accounting for scattering due to immobile scatterers. The components of the cataractogenesis can also be detected by comparing the values of the components of the signature of cataractogenesis to frequency distribution of the components taken from populations or by detecting changes in the values of the components of the signature of cataractogenesis as a function of time.

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Cambridge, MA, United States of America

Douglas L Hayden