Thync Global, Inc.

Ist Corporation, Limited

Thyne Global, Inc.

Thync, Inc.

Douglas Jeffery

Wing Law

Isy Goldwasser

Sumon K Pal

William J Tyler

Jonathan D Charlesworth

Rafal Piersiak

Daniel Z Wetmore

Jay F Hamlin

Remi Demers

Joshua Morenstein

Christopher N HibmaCronan

Matthew Malone

Florent Olivier Alexandre

Anil Thakur

Jason Egnal

Transdermal electrical stimulation (TES) applicators that are wearable and configured to attached to a subject's pinna (ear) and adapted to apply TES to modulate the subject's cognitive and/or physiological state. These apparatuses may be configured so that they can be worn against the ear (e.g., the cymba of the ear) to deliver TES. Also described herein are methods of using them to modulate a subject's cognitive state. These TES applicators may also be adapted to function as audio headphones for concurrent delivery of TES and audible signals (e.g., music).

Methods and apparatuses for transdermal stimulation of the outer ear

Methods and apparatuses for transdermal electrical stimulation. Described herein are single-use or limited-use TES apparatuses and methods of using them that include an integrated (e.g., flex-circuit) electrode assembly and controller apparatus including a waveform generator and power supply. Also described herein are TES apparatuses including a cord or wire having current control circuitry and configured to connect a mobile computing device (e.g., smartphone or wearable electronics) to an electrode assembly. Finally, also described herein are intermediate apparatuses including a flex-circuit electrode assembly including a waveform generator but receiving power from a cable connected to a mobile computing device.

Methods and apparatuses for transdermal electrical stimulation

Apparatuses (e.g., devices, systems), and methods for transdermal electrical stimulation (TES). Apparatuses described herein can be self-contained, lightweight, and wearable. The apparatuses and methods described herein be configured to apply an ensemble current waveform between the two or more electrodes, wherein the ensemble current waveform comprises a series of component waveforms that are sequentially applied, and wherein each component waveform is different from a component waveform immediately before it and wherein transitions between the component waveforms temporally correlates with transitions in the sensory experience. Also described are neurostimulators for application of transdermal electrical stimulation (TES) and methods of using them for comfortably inducing a cognitive effect. Also described are Methods and apparatuses for amplitude modulation of all or a portion of an ensemble waveform to modify a user's cognitive state by transdermal electrical stimulation (TES).

Apparatuses and methods for neuromodulation

Described herein are methods and apparatuses for the application of transdermal electrical stimulation (TES). The apparatuses described herein include neck-worn devices having electrodes (or configured to connect to electrodes, including automatically self-connecting to electrodes) adapted to couple to the midline of the back of user's neck. A neck-worn controller may be configured as a cord, band, wire, torc, necklace, loop, strap, or the like, and may be rigid or semi-rigid and may be worn at least partially around the subject's neck. The controller may controllably apply one or more waveforms to the electrodes of the electrode pad (e.g., patch) to deliver TES adapted to treat a disorder (e.g., psoriasis) and/or to induce or enhance a relaxed cognitive state.

Transdermal electrical stimulation at the neck

Electrodes having an active region formed of a plurality of layers in which one or more conductive layers is formed of a pattern having a plurality of branches and/or holes (e.g. a grid pattern, a snowflake pattern, etc.) to provide a greater density of edges, so that the ratio of edges in the patterned conductive layer to the perimeter of the active region is greater than a minimum value (e.g., 1.5, 2, 3, 4, 5, 6, etc.). The multiple layers may include the patterned conductive layer and a second conductive layer, which may also be patterned, with a less conductive layer sandwiched between them to achieve a more even charge distribution across the face of the active region than in addition to the greater current density provided by the large number of edges.

Electrodes having surface exclusions

Described herein are methods and apparatuses for the application of transdermal electrical stimulation (TES) in order to modulate a user's cognitive state to induce a state of calm or relaxation. The apparatuses described herein include neck-worn devices having electrodes (or configured to connect to electrodes, including automatically self-connecting to electrodes) adapted to couple to the midline of the back of user's neck. A neck-worn controller may be configured as a cord, band, wire, torc, necklace, loop, strap, or the like, and may be rigid or semi-rigid and may be worn at least partially around the subject's neck. The controller may controllably apply one or more waveforms to the electrodes of the electrode pad (e.g., patch) to deliver TES adapted to induce or enhance a relaxed cognitive state.

Transdermal electrical stimulation at the neck to induce neuromodulation

Electrode assembly for a wearable transdermal and transcranial neurostimulator

Electrode assembly for transdermal and transcranial stimulation

Apparatuses (e.g., devices, systems), and methods for transdermal electrical stimulation (TES). Apparatuses described herein can be self-contained, lightweight, and wearable. The apparatus may include a primary unit (TES stimulator) and an electrode portion that includes a first transdermal electrode and a second transdermal electrode and mates with the TES stimulator. The first electrode and secondary electrode are placed at two locations on the skin of a user, for example on the head and/or neck of a user. Electrical stimulation driven between the two electrodes may induce a cognitive effect in a user of the device.

Wearable transdermal electrical stimulation devices and methods of using them

Neurostimulator apparatuses for applying transdermal electrical stimulation that may be comfortably and securely worn on a variety of head shapes and sizes. The apparatuses and methods of using them described herein may be lightweight and wearable and configured to be attached at one end of a patient-facing surface of the apparatus by a cantilevered attachment so that an opposite end of the surface is free to float relative to the user's head. The cantilevered attachment may include two or more connectors spaced apart along an edge region of the patient-facing surface in an optimal arrangement to secure the neurostimulator in place. The neurostimulator apparatuses described herein may be secured to a separate or integral electrode assembly that may adhesively secure to the subject's head. The patient-facing surface of the neurostimulator may also be curved and twisted specifically for use at the temple/forehead region of a diverse population of potential users.

Wearable transdermal neurostimulator having cantilevered attachment

Methods for attaching a wearable neurostimulator to a user's head (or head and neck) using a cantilever electrode apparatuses for neuromodulation. In practice an electrode assembly may mate with the wearable neuromodulation devices so that the device is worn over one portion of the electrode assembly while the rest of the electrode assembly attaches to another portion of the body. The neuromodulator may be worn on a portion of the electrode assembly in a cantilevered manner (e.g., held at one end while the opposite end is free-floating), which allows the rigid neuromodulation device to conform to a variety of user head sizes and shapes.

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San Jose, CA, United States of America

Douglas Jeffery