Focal, Inc.

University of Texas System

Genzyme Corporation

Douglas J Weaver

Amarpreet S Sawhney

Luis Z Avila

Arthur J Coury

Shikha P Barman

Stephen D Goodrich

Ronald S Rudowsky

Fei Yao

William C Nason

Jeffrey Alan Hubbell

David A Melanson

Peter K Jarrett

David J Enscore

Mark T Kieras

Chandrashekar P Pathak

Michelle D Powell

George E Selecman

Dean M Pichon

Michelle D Lyman

Bradley C Poff

David J Nedder

John C Spiridigliozzi

Donald L Elbert

Thomas S Bromander

Marc A Levine

Water-soluble macromers including at least one hydrolysable linkage formed from carbonate or dioxanone groups, at least one water-soluble polymeric block, and at least one polymerizable group, and methods of preparation and use thereof are described. The macromers are preferably polymerized using free radical initiators under the influence of long wavelength ultraviolet light or visible light excitation. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. The macromers can be used to encapsulate cells, deliver prophylactic, therapeutic or diagnostic agents in a controlled manner, plug leaks in tissue, prevent adhesion formation after surgical procedures, temporarily protect or separate tissue surfaces, and adhere or seal tissues together.

Polymerizable biodegradable polymers including carbonate or dioxanone linkages

Redox and photoinitiator systems for priming and improved adherence of

Polymerizable biodegradable polymers including carbonate or dioxanone

An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. The barrier can be prepared by staining tissue with a photoinitiator, applying a solution containing a polymerizable barrier material solution and a photoinitiator to the tissue, and polymerizing the polymer solution on exposure to light. The resulting polymer adheres strongly to the tissue surface, and also forms a gel in the rest of the applied volume. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. The method can be used to adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. Tissue surfaces can be adhered to each other to repair wounds. In addition to photochemical initiators, non-photochemical initiators and combinations of chemical initiators and photochemical initiators can be used.

Redox and photoinitiator priming for improved adherence of gels to

Growing community of inventors

Bedford, MA, United States of America

Douglas J Weaver