Other

Semprus Biosciences Corporation

Douglas J K Weaver

Arthur J Coury

Jeffrey Alan Hubbell

Amarpreet S Sawhney

David A Melanson

John C Spiridigliozzi

Luis Z Avila

Chad Cori Huval

Thomas Bromander

Shikha P Barman

Zheng Zhang

Christopher R Loose

George E Selecman

Stephen D Goodrich

Ronald S Rudowsky

Jun Li

Michael A Bouchard

Mark T Kieras

Dean M Pichon

Bradley C Poff

David J Nedder

Donald L Elbert

Chandrashekar P Pathak

Eric W Marchese

Marc A Levine

Abby N Deleault

Phu C Nguyen

Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.

Articles having non-fouling surfaces and processes for preparing the same without altering bulk physical properties

An impoved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitiator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as &ldquo;priming&rdquo;. The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, &ldquo;priming&rdquo; can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gelable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses. Methods for use of non-photochemical systems and combined chemical/photochemical systems are described.

Redox and photoinitiator systems for priming for improved adherence of gels to substrates

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Cambridge, MA, United States of America

Douglas J K Weaver