Yale University

Polybiotics LLC

Douglas Hanlon

Adam I Lehman

Richard L Edelson

Vincent Mata

Michael Girardi

Carole L Berger

George L Discher, Jr

William H Hylton

According to some embodiments, an apparatus may deliver a medication that comprises a multi-dose syringe, a multi-dose medication storage unit coupled to the multi-dose syringe, and a trigger mechanism. The multi-dose medication storage is to comprise a plurality of pre-loaded doses of a medication where the medication is in powder form. Moreover, the trigger mechanism is to facilitate delivery of one or more of the plurality of doses of the medication from the multi-dose medication storage unit.

Multi-dose delivery system

A method for inducing differentiation of monocytes contained in an extracorporeal quantity of a subject's blood into functional dendritic antigen presenting cells is provided. The monocytes are induced to differentiate into dendritic cells by activation forces resulting from flow of the monocytes through a treatment apparatus having plastic channels. The interior surface of the plastic channel may be modified to increase the available surface area for interaction with blood monocytes. Platelets and serum protein may be removed from the blood prior to treatment to reduce or eliminate contamination of the plastic channel by these blood components. Functional dendritic cells generated from induced monocytes are incubated together with apoptotic or inactivated disease effector agents to enhance the presentation of at least one disease-causing antigen expressed by the disease effector agents. Compositions including dendritic cells derived from induced monocytes and compositions including such dendritic cells incubated with disease effector agents are also provided for use in immunotherapeutic treatment.

Methods for inducing the differentiation of monocytes into functional dendritic cells and immunotherapeutic compositions including such dendritic cells

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Branford, CT, United States of America

Douglas Hanlon