University of California

The J. David Gladstone Institutes

Other

Altor Bioscience Corporation

University of Toronto

Ostrowski, Mario A.

Rini, James M.

Jones, Richard B.

Douglas F Nixon

Paul Klenerman

Martin Bigos

Richard Bradley Jones

Adrian B McDermott

Lishomwa C Ndhlovu

Stephane Champiat

Keith Garrison

Scott Furlan

Mario Ostrowski

Megan Sheehy

James Rini

Luc Kestens

Barbara Shacklett

Wim Jennes

James M Rini

Richard B Jones

Mario A Ostrowski

The application relates to methods of treating chronic viral infection by modulating Tim-3 activity. In addition, the present application relates to methods of diagnosing or monitoring immune system activity or function, chronic viral infection and inflammatory disease using Tim-3 expression.

Methods for inhibiting HIV or HCV infection by administering TIM-3 binding inhibitors

Isolated polypeptides related to endogenous anti-viral polypeptides; and compositions, including immunogenic compositions, comprising a subject isolated polypeptide are disclosed herein. A subject isolated polypeptide comprises an amino acid sequence having substantial amino acid sequence identity to a contiguous stretch of amino acids of one or more endogenous anti-viral polypeptides, wherein the endogenous anti-viral polypeptides are polypeptides subject to proteolytic degradation as a result of the activity of one or more viral proteins. Also provided are diagnostic and treatment methods using the subject isolated polypeptides and compositions.

Method of inducing a T lymphocyte response using T-cell immunogens derived from anti-viral proteins

The application relates to methods of treating a chronic viral infection, such as HIV (Human Immunodeficiency Virus), by modulating Tim-3 activity, whereby blocking the action of Tim-3 on a T cell enhances the immunity to the virus.

Methods of inhibiting viral replication and improving T cell function employing soluble Tim-3 inhibitors

T-cell immunogens derived from anti-viral proteins and methods of using same

The present invention provides a method of detecting antigen-specific T lymphocytes in a sample. The present invention further provides kits and systems for detecting antigen-specific T lymphocytes in a sample.

Method of detecting antigen-specific T lymphocytes

The present invention provides methods of detecting specific lysis of a cell by a lytic agent. The methods generally involve contacting a labeled target cell with a lytic agent; and detecting fluorescence in the target cell. The target cells are labeled with two fluorescent labels: a first fluorescent label that labels the plasma membrane; and a second fluorescent label that labels the cytosol. Release of the cytosolic label from the target cell indicates that the target cell has been lysed. The invention further provides methods of detecting the presence in a sample of a cell that specifically lyses a target cell. The invention further provides methods of detecting the presence in a sample of an antibody that specifically lyses a target cell. The methods are useful in a variety of applications.

Methods of detecting specific cell lysis

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San Francisco, CA, United States of America

Douglas F Nixon