Millennium Pharmaceuticals Limited

Sunovion Pharmaceuticals Inc.

Pgi Drug Discovery LLC

Douglas F Burdi

Shomir Ghosh

Tracy J Jenkins

Gang Li

Bing Guan

Mingshi Dai

Charles A Minor

Robert A Bennett

Michele L R Heffernan

Linghong Xie

Carrie A Bowen

Lee W Herman

Compounds of Formula I are described as are pharmaceutical compositions containing such compounds. Methods of treating neurological or psychiatric diseases and disorders in a subject in need are also disclosed.

Heteroaryl-isochroman compounds and uses thereof

Compounds and uses thereof

The present invention provides compounds of general formula I:  or a pharmaceutically acceptable salt thereof, wherein R, X, Z, R, X, Ar, n, Rand Rare defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.

Aryl sulfonamides useful as inhibitors of chemokine receptor activity

The present invention provides compounds of general formula I: or a pharmaceutically acceptable salt thereof, wherein R, X, Z, R, X, Ar, n, Rand Rare defined generally and in subsets herein. Compounds of the invention are inhibitors of CCR8 and accordingly are useful for the treatment of a variety of inflammatory and allergic disorders.

Disclosed are CCR8 inhibitors represented by Structural Formulas (I):  The variables in Structural Formula (I) are described herein. Also disclosed are methods of treating a subject with a CCR8 mediated condition, especially asthma, by administering one of the disclosed CCR8 inhibitors to the subject.

CCR8 inhibitors

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Arlington, MA, United States of America

Douglas F Burdi