Lonza Sales Ag

Codiak Biosciences, Inc.

Other

Douglas E Williams

John D Kulman

Ke Xu

Damian J Houde

Sriram Sathyanarayanan

Nikki Ross

Sonya Haupt

Rane A Harrison

Kevin P Dooley

Russell E McConnell

Shelly Martin

Yu Zhou

Nuruddeen D Lewis

Leonid A Gaydukov

Young Jun Choi

Konstantin Konstantinov

Delai Chen

Christine M Williams

Raymond W Bourdeau

Michael Doherty

Aaron R Noyes

Dalia Burzyn

Adam Thomas Boutin

Sushrut Kamerkar

Russell E Mcconnell

Kathryn E Golden

Michael P Mercaldi

Madeleine Youniss

Scott D Estes

Tik Yan Chan

Andrew F Grube

Agata A Villiger

Methods of loading extracellular vesicles with payload molecules via homogenization are disclosed herein.

Loading of extracellular vesicles through imparting of mechanical shear

Disclosed herein are extracellular vesicles comprising an immunomodulating component. Also provided are methods for producing the extracellular vesicles and methods for using the extracellular vesicles for treating cancer, GvHD, and autoimmune diseases.

Exosomes for immuno-oncology and anti-inflammatory therapy

The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.

Preparation of therapeutic exosomes using membrane proteins

Described herein are novel rapid and reliable methods of detection of extracellular vesicles and quantifying extracellular vesicle concentrations and absolute number from various sources, including raw cell harvest. The methods described herein comprise detection of intrinsic fluorescence of extracellular vesicles in biological samples. Extracellular vesicles analyzed by the methods of this application have a stereotypical elution profile distinct from known contaminants. The methods described herein are a significant improvement over the state of the art and fulfills an unmet need in the field of extracellular vesicle manufacturing and quality control.

Methods of measuring exosomes using intrinsic fluorescence

Described herein are novel rapid and reliable methods of detection of extracellular vesicles and quantifying extracellular vesicle concentrations and absolute number from various sources, including raw cell harvest. The methods described herein comprise detection of light scattering of extracellular vesicles in biological samples. Extracellular vesicles analyzed by the methods of this application have a stereotypical elution profile distinct from known contaminants. The methods described herein are a significant improvement over the state of the art and fulfills an unmet need in the field of extracellular vesicle manufacturing and quality control.

Methods of measuring extracellular vesicles and nanoparticles in complex matrices by light scattering

Disclosed herein are compositions and methods comprising extracellular vesicles comprising nucleic acid that target genes, leading to macrophage polarization of tumor associated macrophages. In certain embodiments, disclosed herein are methods and compositions for increasing macrophage polarization for the treatment of cancer.

Methods and compositions for macrophage polarization

Wheel rim guard

Video presentation apparatus

End coupler for fume exhaust ducts

Growing community of inventors

Boston, MA, United States of America

Douglas E Williams