Fmc Corporation

Fmc Corporation, Lithium Division

Douglas E Sutton

James Anthony Schwindeman

Christopher Jay Woltermann

Robert C Morrison

Eric J Granger

Sonia S Stryker

Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with pyridinic compounds to produce functionalized pyridinic compounds.

Using alkylmetal reagents for directed metalation of azaaromatics

Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with azaaromatic compounds and/or nitrogen heterocycle compounds to produce functionalized azaaromatic compounds and functionalized nitrogen heterocycle compounds.

A process for preparing functionalized alkyllithium compounds includes reacting in an inert solvent a protected functionalized alkyl halide with an alkali metal in the presence of a catalytic compound of the formula

Processes for preparing functionalized alkyllithium compounds

An improved process for producing high purity solutions of aryllithium compounds comprising reacting a particulate alkali metal having a particle size in the range of 10 to 300 microns, with an aryl halide in a normally liquid etheral solvent of the formula ROR.sup.1, wherein R and R.sup.1 are selected from the group of alkyl radicals containing from 3 to 6 carbon atoms, in the presence of a Lewis base compound selected from compounds of the formula: R.sup.2 AR.sup.3 (R.sup.4).sub.z and ##STR1## wherein A is selected from oxygen, nitrogen, phosphorus or sulfur; R.sup.2, R.sup.3, and R.sup.4 are selected from alkyl radicals containing from 1 to 6 carbon atoms; R.sup.5 and R.sup.6 are independently selected from hydrogen or alkyl radicals containing one to six carbon atoms; y is an integer from 4 to 6; but when A is oxygen or sulfur, z is zero; and when A is nitrogen or phosphorus, z is one, and provided there is a mole ratio of ether to aryl halide of at least 1.3 to 1 and a mole ratio of Lewis base to aryl halide of from 0.01 to 0.50; and products of the process.

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Kings Mountain, NC, United States of America

Douglas E Sutton