Sarepta Therapeutics, Inc.

Avi Biopharma, Inc.

Douglas E Skilling

Patrick L Iversen

David A Stein

Alvin W Smith

Dwight D Weller

The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of viruses of the picornavirus, calicivirus, togavirus and flavivirus families, as in treatment of a viral infection. The antisense antiviral compounds have morpholino subunits linked by uncharged phosphorodiamidate linkages interspersed with cationic phosphorodiamidate linkages.

Antisense antiviral agent and method for treating ssRNA viral infection

The invention provides antisense antiviral compounds and methods of their use in inhibition of growth of viruses of the picornavirus, calicivirus, togavirus and flavivirus families, as in treatment of a viral infection. The antisense antiviral compounds are substantially uncharged oligomers having a targeting base sequence that is substantially complementary to a viral target sequence which spans the AUG start site of the first open reading frame of the viral genome.

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Corvallis, OR, United States of America

Douglas E Skilling