University of Virginia Patent Foundation

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Other

Johns Hopkins University

Douglas E Lake

J Randall Moorman

Brynne Sullivan

Karen D Fairchild

Gordon Tomaselli

Deeptankar Demazumder

John B Delos

Abigail Flower

Randall Moorman

A method and system for generating pulse oximetry predictive scores (POPS) for predicting adverse outcomes in preterm infants. The method comprising generating a POPS via a predictive algorithm which incorporates cross-correlation of heart rate and SpO2 calculated on archived pulse oximetry data of multiple preterm infants, and predicting a pathology of a preterm infant based on the generated POPS, wherein the pathology is intraventricular hemorrhage, late-onset sepsis, necrotizing enterocolitis, bronchopulmonary dysplasia, or retinopathy of prematurity, and informing a user of an opportunity to: identify the preterm infant as a highest risk infant and perform additional surveillance of or therapeutic intervention on the preterm infant, identify the preterm infant for participation in a clinical trial based on a risk profile associated with the POPS, and treat said preterm infant for the pathology.

Method, system, and computer readable medium for generating pulse oximetry predictive scores (POPS) for predicting adverse outcomes in preterm infants

A system for classifying cardiac rhythms is disclosed. The system includes one or more processors, one or more computer-readable tangible storage devices, and program instructions stored on at least one of the one or more storage devices for execution by at least one of the one or more processors. The program instructions include first program instructions to obtain data representative of a time series of the times between heartbeats. The program instructions further comprise second program instructions to segment the time series into a plurality of segments. The program instructions further comprise third program instructions to calculate a plurality of parameters corresponding to each of the 30-second segments. The program instructions further comprise fourth program instructions to analyze the obtained data and the calculated parameters using a plurality of multivariable algorithms for rhythm classification. The program instructions further comprise fifth program instructions to synthesize the results of the plurality of multivariable algorithms to formulate a single rhythm classification.

System and method for improved cardiac rhythm classification from the time between heart beat intervals using non-linear dynamics

A method and system for generating pulse oximetry predictive scores for predicting adverse outcomes in preterm infants.

A method for analysis of cardiac rhythms, based on calculations of entropy and moments of interbeat intervals. An optimal determination of segments of data is provided that demonstrate statistical homogeneity, specifically with regard to moments and entropy. The invention also involves calculating moments and entropy on each segment with the goal of diagnosis of cardiac rhythm. More specifically, an absolute entropy measurement is calculated and provided as a continuous variable, providing dynamical information of fundamental importance in diagnosis and analysis. Through the present invention, standard histograms, thresholds, and categories can be avoided.

Analysis of cardiac rhythm using RR interval characterization

A method of determining health and mortality includes obtaining a ventricular activation (RR) time series from a subject for multiple temporal intervals. The method also includes calculating a cardiac entropy in the RR time series over the temporal intervals using coefficient of sample entropy (COSEn). Additionally, the method includes comparing the cardiac entropy between the intervals to determine health and mortality. The absolute and relative changes in entropy over a patient's follow up period provide dynamic information regarding health and mortality risk. The determination of health and mortality can then be used to create a treatment plan for the subject.

Ventricular activation (RR) entropy change as a predictor of sudden cardiac death in cardiac resynchronization therapy patients

The invention relates to a method for analysis of cardiac rhythms, based on calculations of entropy and moments of interbeat intervals. The invention provides an optimal determination of segments of data that demonstrate statistical homogeneity, specifically with regard to moments and entropy. The invention also involves calculating moments and entropy on each segment with the goal of diagnosis of cardiac rhythm. More specifically, an absolute entropy measurement is calculated and provided as a continuous variable, providing dynamical information of fundamental importance in diagnosis and analysis. Through the present invention, standard histograms, thresholds, and categories can be avoided.

Method, system and computer program product for non-invasive classification of cardiac rhythm

Method, system, and computer program method for detecting pathological fluctuations of physiological signals to diagnose human illness. The method comprises performing a sliding window analysis to find sequences in physiological signal data that match amplitude- and duration-adjusted versions of a template function to within a specified tolerance.

Method, system and computer program method for detection of pathological fluctuations of physiological signals to diagnose human illness

A method for analysis of cardiac rhythm and RR interval time series based on entropy related data and entropy based measures. The information is related to but distinct from entropy, and is derived from histograms of interval match counts in which the y-axis is the frequency of intervals of length in that have the match count given on the x-axis. The phenotype of the histogram informs on the presence of atrial fibrillation or, in the presence of sinus rhythm, the degree of congestive heart failure.

System, method and computer program product for detection of changes in health status and risk of imminent illness

An improved fluid-filled breast prosthesis for implantation which permits subsequent alterations in the fluid volume of the implant without the necessity for major surgery. The prosthesis comprises a flexible plastic bag having an elongated filler tube including a loop near its outer end. After the prosthesis has been interposed into the surgically prepared implant site, the filler tube is drawn out through a small stab wound connected to the site which terminates adjacent the arm pit. After the plastic bag is filled with fluid, the filler tube is plugged and clamped, and the loop is sutured to the tissue to hold the implant in place. The radiopaque nature of the plug and clamp, and a connected filament, enable the end of the tube to be readily located and grasped subsequent to the operation, using a simple office procedure to adjust the volume of fluid in the bag.

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Charlottesville, VA, United States of America

Douglas E Lake