University of Pennsylvania

Douglas Durian

Andrea J Liu

Menachem Stern

Seyyed Salili

Matthew Harrington

Samuel Dillavou

Marc Z Miskin

A system for physics-based learning and computation including two networks, each having a plurality of identical edges and feedback circuitry to compare the voltage drop at a given edge of the first network with the voltage drop at the corresponding edge of the second network. In both networks, at least one corresponding node is designated for input and at least one corresponding node is designated for output. In the first network, the at least one output node remains free and produces output voltage in response to the input voltage(s). In the second network, the at least one output node is clamped at voltage(s) closer to the desired value for the specified input voltage(s). Feedback circuitry compares voltages across corresponding edges and adjusts their effective resistances in order to learn.

Coupled networks for physics-based machine learning

Systems and methods for passive multi-directional illumination in light-sheet fluorescence imaging and microscopy are disclosed herein. An elliptical light shaping diffuser is placed in the illumination path between the source of a light-sheet and the illuminated sample. The light-sheet is diffused anisotropically along two directions perpendicular to its propagation direction, eliminating stripe artifacts in obtained images. The method includes converting a light-sheet into an elliptically diffuse light-sheet by passing it through an elliptical light shaping diffuser, illuminating a sample with the elliptically diffuse light-sheet. The system includes a light-sheet source, an elliptical light shaping diffuser adapted to convert the light-sheet into an elliptically diffuse light-sheet to illuminate the sample, typical microscopy optics and lenses, and image capturing elements.

Light-sheet fluorescence imaging with elliptical light shaping diffuser

Growing community of inventors

Swarthmore, PA, United States of America

Douglas Durian